Squamous cell carcinoma of the buccal mucosa: One institution's experience with 119 previously untreated patients

Eduardo M. Diaz, F. Christopher Holsinger, Edgar R. Zuniga, Dianna B. Roberts, Douglas M. Sorensen

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Background. Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC. Methods. We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded. Results. Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful. Conclusions. SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalHead and Neck
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2003

Fingerprint

Mouth Mucosa
Squamous Cell Carcinoma
Mouth
Mouth Neoplasms
Survival
Salivary Ducts
Recurrence
Cheek
Neoplasms
Radiotherapy
Survival Rate
Lymph Nodes
Muscles

Keywords

  • Buccal mucosa
  • Oral cavity
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Squamous cell carcinoma of the buccal mucosa : One institution's experience with 119 previously untreated patients. / Diaz, Eduardo M.; Holsinger, F. Christopher; Zuniga, Edgar R.; Roberts, Dianna B.; Sorensen, Douglas M.

In: Head and Neck, Vol. 25, No. 4, 01.04.2003, p. 267-273.

Research output: Contribution to journalArticle

Diaz, Eduardo M. ; Holsinger, F. Christopher ; Zuniga, Edgar R. ; Roberts, Dianna B. ; Sorensen, Douglas M. / Squamous cell carcinoma of the buccal mucosa : One institution's experience with 119 previously untreated patients. In: Head and Neck. 2003 ; Vol. 25, No. 4. pp. 267-273.
@article{15bbfcb3fe314eeda3f8f869e9d8a6b8,
title = "Squamous cell carcinoma of the buccal mucosa: One institution's experience with 119 previously untreated patients",
abstract = "Background. Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC. Methods. We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded. Results. Patients with T1- or T2-sized tumors had only a 78{\%} and 66{\%} 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful. Conclusions. SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites.",
keywords = "Buccal mucosa, Oral cavity, Squamous cell carcinoma",
author = "Diaz, {Eduardo M.} and Holsinger, {F. Christopher} and Zuniga, {Edgar R.} and Roberts, {Dianna B.} and Sorensen, {Douglas M.}",
year = "2003",
month = "4",
day = "1",
doi = "10.1002/hed.10221",
language = "English (US)",
volume = "25",
pages = "267--273",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Squamous cell carcinoma of the buccal mucosa

T2 - One institution's experience with 119 previously untreated patients

AU - Diaz, Eduardo M.

AU - Holsinger, F. Christopher

AU - Zuniga, Edgar R.

AU - Roberts, Dianna B.

AU - Sorensen, Douglas M.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Background. Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC. Methods. We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded. Results. Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful. Conclusions. SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites.

AB - Background. Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC. Methods. We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded. Results. Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful. Conclusions. SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites.

KW - Buccal mucosa

KW - Oral cavity

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0037378817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037378817&partnerID=8YFLogxK

U2 - 10.1002/hed.10221

DO - 10.1002/hed.10221

M3 - Article

C2 - 12658730

AN - SCOPUS:0037378817

VL - 25

SP - 267

EP - 273

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 4

ER -