Squaraine rotaxanes: Superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

James R. Johnson; Na Fu; Easwaran Arunkumar; W. Matthew Leevy; Seth T. Gammon; David Piwnica-Worms; Bradley D. Smith

doi:10.1002/anie.200701491

Squaraine rotaxanes: Superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

James R. Johnson, Na Fu, Easwaran Arunkumar, W. Matthew Leevy, Seth T. Gammon, David Piwnica-Worms, Bradley D. Smith

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

(Figure Presented) It's hip to be square: Squaraine rotaxanes have very similar photophysical properties to the commonly used Cy-5 fluorophore, but are substantially more photostable and resist self-quenching upon aggregation. Molecular probes containing squaraine rotaxanes (see structure) are shown to be versatile, high-performance NIR fluorescence stains for in vitro fluorescence imaging of cells (middle) and in vivo whole-body imaging of living mice (right).

Original language	English (US)
Pages (from-to)	5528-5531
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	29
DOIs	https://doi.org/10.1002/anie.200701491
State	Published - 2007
Externally published	Yes

Keywords

Cell recognition
Dyes/pigments
Fluorescence
Imaging agents
Rotaxanes

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200701491

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abstract = "(Figure Presented) It's hip to be square: Squaraine rotaxanes have very similar photophysical properties to the commonly used Cy-5 fluorophore, but are substantially more photostable and resist self-quenching upon aggregation. Molecular probes containing squaraine rotaxanes (see structure) are shown to be versatile, high-performance NIR fluorescence stains for in vitro fluorescence imaging of cells (middle) and in vivo whole-body imaging of living mice (right).",

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T2 - Superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

AU - Johnson, James R.

AU - Fu, Na

AU - Arunkumar, Easwaran

AU - Leevy, W. Matthew

AU - Gammon, Seth T.

AU - Piwnica-Worms, David

AU - Smith, Bradley D.

PY - 2007

Y1 - 2007

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AB - (Figure Presented) It's hip to be square: Squaraine rotaxanes have very similar photophysical properties to the commonly used Cy-5 fluorophore, but are substantially more photostable and resist self-quenching upon aggregation. Molecular probes containing squaraine rotaxanes (see structure) are shown to be versatile, high-performance NIR fluorescence stains for in vitro fluorescence imaging of cells (middle) and in vivo whole-body imaging of living mice (right).

KW - Cell recognition

KW - Dyes/pigments

KW - Fluorescence

KW - Imaging agents

KW - Rotaxanes

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Squaraine rotaxanes: Superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

Abstract

Keywords

ASJC Scopus subject areas

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