Squaraine rotaxanes: Superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

James R. Johnson, Na Fu, Easwaran Arunkumar, W. Matthew Leevy, Seth T. Gammon, David Piwnica-Worms, Bradley D. Smith

    Research output: Contribution to journalArticle

    140 Scopus citations

    Abstract

    (Figure Presented) It's hip to be square: Squaraine rotaxanes have very similar photophysical properties to the commonly used Cy-5 fluorophore, but are substantially more photostable and resist self-quenching upon aggregation. Molecular probes containing squaraine rotaxanes (see structure) are shown to be versatile, high-performance NIR fluorescence stains for in vitro fluorescence imaging of cells (middle) and in vivo whole-body imaging of living mice (right).

    Original languageEnglish (US)
    Pages (from-to)5528-5531
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume46
    Issue number29
    DOIs
    StatePublished - Aug 1 2007

    Keywords

    • Cell recognition
    • Dyes/pigments
    • Fluorescence
    • Imaging agents
    • Rotaxanes

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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