State of human papilloma virus DNA in cervical carcinomas

F. L. Kisseljov, N. P. Kisseljova, V. K. Kobzeva, T. M. Gritsko, L. A. Semenova, L. S. Pavlova, R. Klaes, Magnus von Knebel Doeberitz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cervical carcinoma is etiologically associated with the human papilloma virus (HPV), HPV 16 and HPV 18 being the most common. Viral DNA is thought to persist mostly in the episomal form in early tumor development, and in the integrated form in carcinomas. This assumption was checked with a new method that discriminated between RNAs transcribed from episomal and integrated HPV DNAs. Both forms were detected in carcinomas of Russian patients regardless of the disease stage. The data were verified by two other methods. RNA with sequences of the HPV transforming gene E7 proved to be transcribed from either DNA form. The results suggest that HPV integration is not crucial for carcinoma progression.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalMolecular Biology
Volume35
Issue number3
DOIs
StatePublished - May 1 2001

Fingerprint

Papillomaviridae
Carcinoma
DNA
Virus Integration
Viral DNA
Oncogenes
RNA

Keywords

  • Cervical carcinoma
  • DNA
  • Episome
  • Expression
  • Integration
  • Papilloma virus

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

Cite this

Kisseljov, F. L., Kisseljova, N. P., Kobzeva, V. K., Gritsko, T. M., Semenova, L. A., Pavlova, L. S., ... von Knebel Doeberitz, M. (2001). State of human papilloma virus DNA in cervical carcinomas. Molecular Biology, 35(3), 399-404. https://doi.org/10.1023/A:1010430913634

State of human papilloma virus DNA in cervical carcinomas. / Kisseljov, F. L.; Kisseljova, N. P.; Kobzeva, V. K.; Gritsko, T. M.; Semenova, L. A.; Pavlova, L. S.; Klaes, R.; von Knebel Doeberitz, Magnus.

In: Molecular Biology, Vol. 35, No. 3, 01.05.2001, p. 399-404.

Research output: Contribution to journalArticle

Kisseljov, FL, Kisseljova, NP, Kobzeva, VK, Gritsko, TM, Semenova, LA, Pavlova, LS, Klaes, R & von Knebel Doeberitz, M 2001, 'State of human papilloma virus DNA in cervical carcinomas', Molecular Biology, vol. 35, no. 3, pp. 399-404. https://doi.org/10.1023/A:1010430913634
Kisseljov FL, Kisseljova NP, Kobzeva VK, Gritsko TM, Semenova LA, Pavlova LS et al. State of human papilloma virus DNA in cervical carcinomas. Molecular Biology. 2001 May 1;35(3):399-404. https://doi.org/10.1023/A:1010430913634
Kisseljov, F. L. ; Kisseljova, N. P. ; Kobzeva, V. K. ; Gritsko, T. M. ; Semenova, L. A. ; Pavlova, L. S. ; Klaes, R. ; von Knebel Doeberitz, Magnus. / State of human papilloma virus DNA in cervical carcinomas. In: Molecular Biology. 2001 ; Vol. 35, No. 3. pp. 399-404.
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