STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling

Shuwen Yang, Qinghai Ji, Bin Chang, Yan Wang, Yongxue Zhu, Duanshu Li, Caiping Huang, Yulong Wang, Guohua Sun, Ling Zhang, Qing Guan, Jun Xiang, Wenjun Wei, Zhongwu Lu, Tian Liao, Jiao Meng, Ziliang Wang, Ben Ma, Li Zhou, Yu WangGong Yang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC. Using in vitro and in vivo assays, we show that overexpression of STC2 suppressed cell apoptosis, promoted cell proliferation, migration, invasion, and cell cycle arrest at the G1/S transition. By contrast, silencing of STC2 inhibited these activities. We further show that STC2 upregulated the phosphorylation of AKT and enhanced HNSCC metastasis via Snail-mediated increase of vimentin and decrease of E-cadherin. These responses were blocked by silencing of STC2/Snail expression or inhibition of pAKT activity. Furthermore, clinical data indicate that high STC2 expression was associated with high levels of pAKT and Snail in tumor samples from HNSCC patients with regional lymph node metastasis (P < 0.01). Thus, we conclude that STC2 controls HNSCC metastasis via the PI3K/AKT/ Snail signaling axis and that targeted therapy against STC2 may be a novel strategy to effectively treat patients with metastatic HNSCC.

Original languageEnglish (US)
Pages (from-to)5976-5991
Number of pages16
JournalOncotarget
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2017

Fingerprint

Snails
Phosphatidylinositol 3-Kinases
Neoplasm Metastasis
teleocalcin
Carcinoma, squamous cell of head and neck
G1 Phase Cell Cycle Checkpoints
Peptide Hormones
Vimentin
Cadherins
Cell Movement
Neoplasms
Lymph Nodes
Phosphorylation
Cell Proliferation
Apoptosis

Keywords

  • HNSCC
  • Metastasis
  • PAKT
  • STC2
  • Snail

ASJC Scopus subject areas

  • Oncology

Cite this

STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. / Yang, Shuwen; Ji, Qinghai; Chang, Bin; Wang, Yan; Zhu, Yongxue; Li, Duanshu; Huang, Caiping; Wang, Yulong; Sun, Guohua; Zhang, Ling; Guan, Qing; Xiang, Jun; Wei, Wenjun; Lu, Zhongwu; Liao, Tian; Meng, Jiao; Wang, Ziliang; Ma, Ben; Zhou, Li; Wang, Yu; Yang, Gong.

In: Oncotarget, Vol. 8, No. 4, 01.01.2017, p. 5976-5991.

Research output: Contribution to journalArticle

Yang, S, Ji, Q, Chang, B, Wang, Y, Zhu, Y, Li, D, Huang, C, Wang, Y, Sun, G, Zhang, L, Guan, Q, Xiang, J, Wei, W, Lu, Z, Liao, T, Meng, J, Wang, Z, Ma, B, Zhou, L, Wang, Y & Yang, G 2017, 'STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling', Oncotarget, vol. 8, no. 4, pp. 5976-5991. https://doi.org/10.18632/oncotarget.13355
Yang, Shuwen ; Ji, Qinghai ; Chang, Bin ; Wang, Yan ; Zhu, Yongxue ; Li, Duanshu ; Huang, Caiping ; Wang, Yulong ; Sun, Guohua ; Zhang, Ling ; Guan, Qing ; Xiang, Jun ; Wei, Wenjun ; Lu, Zhongwu ; Liao, Tian ; Meng, Jiao ; Wang, Ziliang ; Ma, Ben ; Zhou, Li ; Wang, Yu ; Yang, Gong. / STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. In: Oncotarget. 2017 ; Vol. 8, No. 4. pp. 5976-5991.
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AU - Ji, Qinghai

AU - Chang, Bin

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AU - Li, Duanshu

AU - Huang, Caiping

AU - Wang, Yulong

AU - Sun, Guohua

AU - Zhang, Ling

AU - Guan, Qing

AU - Xiang, Jun

AU - Wei, Wenjun

AU - Lu, Zhongwu

AU - Liao, Tian

AU - Meng, Jiao

AU - Wang, Ziliang

AU - Ma, Ben

AU - Zhou, Li

AU - Wang, Yu

AU - Yang, Gong

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