Strategies to reverse endothelial dysfunction in diabetic nephropathy

Shawn S. Badal; Farhad R. Danesh

doi:10.1038/ki.2012.306

Strategies to reverse endothelial dysfunction in diabetic nephropathy

Shawn S. Badal, Farhad R. Danesh

General Internal Medicine

Research output: Contribution to journal › Comment/debate › peer-review

14 Scopus citations

Abstract

Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.

Original language	English (US)
Pages (from-to)	1151-1154
Number of pages	4
Journal	Kidney International
Volume	82
Issue number	11
DOIs	https://doi.org/10.1038/ki.2012.306
State	Published - Dec 1 2012

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2012.306

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abstract = "Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.",

author = "Badal, {Shawn S.} and Danesh, {Farhad R.}",

note = "Funding Information: This work was supported by National Institutes of Health grants to F.R.D. (DK091310 and DK078900), and a training grant to S.S.B. (T32-GM88129).",

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AU - Danesh, Farhad R.

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N2 - Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.

AB - Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.

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Strategies to reverse endothelial dysfunction in diabetic nephropathy

Abstract

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