Streptozocin-Treated Verner-Morrison Syndrome: Plasma Vasoactive Intestinal Peptide and Tumor Responses

Robert F. Gagel; Mary E. Costanza; Ronald A. Delellis; Richard A. Norton; Stephen R. Bloom; Harry H. Miller; Angelo Ucci; Larry Nathanson

doi:10.1001/archinte.1976.03630120075019

Streptozocin-Treated Verner-Morrison Syndrome: Plasma Vasoactive Intestinal Peptide and Tumor Responses

Robert F. Gagel, Mary E. Costanza, Ronald A. Delellis, Richard A. Norton, Stephen R. Bloom, Harry H. Miller, Angelo Ucci, Larry Nathanson

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A patient with watery diarrhea, hypokalemia, hypochlorhydria, and a non-beta islet cell carcinoma of the pancreas (Verner-Morrison syndrome) was found to have an elevated vasoactive intestinal peptide (VIP) concentration in the plasma as well as in the tumor. Treatment with streptozocin resulted in a dramatic subjective and objective tumor response in this patient. Plasma VIP concentration fell into the normal range after four courses of treatment, diarrhea ceased after the third course of therapy, and measurable tumor mass markedly decreased during that same period of time. The patient remains in clinical remission with no evidence of tumor regrowth 18 months after the beginning of treatment. In this patient, plasma VIP measurements were an excellent marker of tumor activity and correlated well with objective disease measurements and clinical response.

Original language	English (US)
Pages (from-to)	1429-1435
Number of pages	7
Journal	Archives of Internal Medicine
Volume	136
Issue number	12
DOIs	https://doi.org/10.1001/archinte.1976.03630120075019
State	Published - Dec 1976
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1001/archinte.1976.03630120075019

Cite this

@article{a87e3315a2634efe874d61d1b14052df,

title = "Streptozocin-Treated Verner-Morrison Syndrome: Plasma Vasoactive Intestinal Peptide and Tumor Responses",

abstract = "A patient with watery diarrhea, hypokalemia, hypochlorhydria, and a non-beta islet cell carcinoma of the pancreas (Verner-Morrison syndrome) was found to have an elevated vasoactive intestinal peptide (VIP) concentration in the plasma as well as in the tumor. Treatment with streptozocin resulted in a dramatic subjective and objective tumor response in this patient. Plasma VIP concentration fell into the normal range after four courses of treatment, diarrhea ceased after the third course of therapy, and measurable tumor mass markedly decreased during that same period of time. The patient remains in clinical remission with no evidence of tumor regrowth 18 months after the beginning of treatment. In this patient, plasma VIP measurements were an excellent marker of tumor activity and correlated well with objective disease measurements and clinical response.",

author = "Gagel, {Robert F.} and Costanza, {Mary E.} and Delellis, {Ronald A.} and Norton, {Richard A.} and Bloom, {Stephen R.} and Miller, {Harry H.} and Angelo Ucci and Larry Nathanson",

year = "1976",

month = dec,

doi = "10.1001/archinte.1976.03630120075019",

language = "English (US)",

volume = "136",

pages = "1429--1435",

journal = "Archives of Internal Medicine",

issn = "0003-9926",

publisher = "American Medical Association",

number = "12",

}

TY - JOUR

T1 - Streptozocin-Treated Verner-Morrison Syndrome

T2 - Plasma Vasoactive Intestinal Peptide and Tumor Responses

AU - Gagel, Robert F.

AU - Costanza, Mary E.

AU - Delellis, Ronald A.

AU - Norton, Richard A.

AU - Bloom, Stephen R.

AU - Miller, Harry H.

AU - Ucci, Angelo

AU - Nathanson, Larry

PY - 1976/12

Y1 - 1976/12

N2 - A patient with watery diarrhea, hypokalemia, hypochlorhydria, and a non-beta islet cell carcinoma of the pancreas (Verner-Morrison syndrome) was found to have an elevated vasoactive intestinal peptide (VIP) concentration in the plasma as well as in the tumor. Treatment with streptozocin resulted in a dramatic subjective and objective tumor response in this patient. Plasma VIP concentration fell into the normal range after four courses of treatment, diarrhea ceased after the third course of therapy, and measurable tumor mass markedly decreased during that same period of time. The patient remains in clinical remission with no evidence of tumor regrowth 18 months after the beginning of treatment. In this patient, plasma VIP measurements were an excellent marker of tumor activity and correlated well with objective disease measurements and clinical response.

AB - A patient with watery diarrhea, hypokalemia, hypochlorhydria, and a non-beta islet cell carcinoma of the pancreas (Verner-Morrison syndrome) was found to have an elevated vasoactive intestinal peptide (VIP) concentration in the plasma as well as in the tumor. Treatment with streptozocin resulted in a dramatic subjective and objective tumor response in this patient. Plasma VIP concentration fell into the normal range after four courses of treatment, diarrhea ceased after the third course of therapy, and measurable tumor mass markedly decreased during that same period of time. The patient remains in clinical remission with no evidence of tumor regrowth 18 months after the beginning of treatment. In this patient, plasma VIP measurements were an excellent marker of tumor activity and correlated well with objective disease measurements and clinical response.

UR - http://www.scopus.com/inward/record.url?scp=84942482545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942482545&partnerID=8YFLogxK

U2 - 10.1001/archinte.1976.03630120075019

DO - 10.1001/archinte.1976.03630120075019

M3 - Article

C2 - 187136

AN - SCOPUS:84942482545

SN - 0003-9926

VL - 136

SP - 1429

EP - 1435

JO - Archives of Internal Medicine

JF - Archives of Internal Medicine

IS - 12

ER -

Streptozocin-Treated Verner-Morrison Syndrome: Plasma Vasoactive Intestinal Peptide and Tumor Responses

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this