TY - JOUR
T1 - Stress, inflammation, and eicosanoids
T2 - an emerging perspective
AU - Umamaheswaran, Sujanitha
AU - Dasari, Santosh K.
AU - Yang, Peiying
AU - Lutgendorf, Susan K.
AU - Sood, Anil K.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.
AB - Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.
KW - Cancer
KW - Eicosanoids
KW - Inflammation
KW - PGE
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85048281778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048281778&partnerID=8YFLogxK
U2 - 10.1007/s10555-018-9741-1
DO - 10.1007/s10555-018-9741-1
M3 - Article
C2 - 29948328
AN - SCOPUS:85048281778
SN - 0167-7659
VL - 37
SP - 203
EP - 211
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 2-3
ER -