Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53

Jiansen Li, Xiangqian Zheng, Ming Gao, Jingzhu Zhao, Yigong Li, Xiangrui Meng, Biyun Qian, Jiafeng Li

    Research output: Contribution to journalArticle

    3 Scopus citations

    Abstract

    Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular domain could not be detected in ATC-CAL-62 cells. Interesting, suberoyl bis-hydroxamic acid (SBHA) administration could induce Notch1 intracellular domain levels in a dose-dependent manner, coupled with the increase of p53 and p21. Furthermore, ectopic expression of Notch1 or deletion of p53 with smallinterfering RNA was able to abolish the effects of SBHA to elevation of Notch1 and p53 in ATC cells. As a result, SBHA treatment efficiently induced ATC cell apoptosis. These results indicate that SBHA may play antitumor functions via regulating Notch1/p53 signals, and highlight that SBHA could have clinical potential to benefit the therapy of ATC patients.

    Original languageEnglish (US)
    Pages (from-to)458-464
    Number of pages7
    JournalOncology reports
    Volume37
    Issue number1
    DOIs
    StatePublished - Jan 2017

    Keywords

    • Anaplastic thyroid cancer
    • Apoptosis
    • Notch1
    • Suberoyl bis-hydroxamic acid
    • p21
    • p53

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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