Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia: A case report and review of the literature

Naveen Pemmaraju; Koji Sasaki; Daniel Johnson; Naval Daver; Vahid Afshar-Kharghan; Merry Chen; Sairah Ahmed; Rivka R. Colen; Michael Kwon; Yang Huh; Gautam Borthakur

doi:10.3389/fonc.2015.00029

Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia: A case report and review of the literature

Naveen Pemmaraju, Koji Sasaki, Daniel Johnson, Naval Daver, Vahid Afshar-Kharghan, Merry Chen, Sairah Ahmed, Rivka R. Colen, Michael Kwon, Yang Huh, Gautam Borthakur

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2 Scopus citations

Abstract

Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven®)] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML.

Original language	English (US)
Article number	029
Journal	Frontiers in Oncology
Volume	5
Issue number	FEB
DOIs	https://doi.org/10.3389/fonc.2015.00029
State	Published - 2015

Keywords

Acute myeloid leukemia
Intracranial hemorrhage
Recombinant activated factor VII

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2015.00029

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Pemmaraju, N., Sasaki, K., Johnson, D., Daver, N., Afshar-Kharghan, V., Chen, M., Ahmed, S., Colen, R. R., Kwon, M., Huh, Y., & Borthakur, G. (2015). Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia: A case report and review of the literature. Frontiers in Oncology, 5(FEB), Article 029. https://doi.org/10.3389/fonc.2015.00029

Pemmaraju, N , Sasaki, K, Johnson, D, Daver, N , Afshar-Kharghan, V , Chen, M , Ahmed, S, Colen, RR, Kwon, M, Huh, Y & Borthakur, G 2015, 'Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia: A case report and review of the literature', Frontiers in Oncology, vol. 5, no. FEB, 029. https://doi.org/10.3389/fonc.2015.00029

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abstract = "Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven{\textregistered})] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML.",

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author = "Naveen Pemmaraju and Koji Sasaki and Daniel Johnson and Naval Daver and Vahid Afshar-Kharghan and Merry Chen and Sairah Ahmed and Colen, {Rivka R.} and Michael Kwon and Yang Huh and Gautam Borthakur",

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AU - Pemmaraju, Naveen

AU - Sasaki, Koji

AU - Johnson, Daniel

AU - Daver, Naval

AU - Afshar-Kharghan, Vahid

AU - Chen, Merry

AU - Ahmed, Sairah

AU - Colen, Rivka R.

AU - Kwon, Michael

AU - Huh, Yang

AU - Borthakur, Gautam

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AB - Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven®)] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML.

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Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia: A case report and review of the literature

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