TY - JOUR
T1 - SU‐DD‐A4‐05
T2 - Effects of Pixel Size and OSEM Iteration Parameters On Tc‐99m SPECT Resolution
AU - Kappadath, S.
AU - Erwin, W.
PY - 2009/6
Y1 - 2009/6
N2 - Purpose: To evaluate the effect of pixel size and OSEM iterative reconstruction parameters on radial (RR) and tangential (TR) Tc‐99m SPECT resolution versus distance from isocenter. Method and Materials: Ten high‐concentration Tc‐99m point sources of size <2mm3 were positioned coplanar 0–9 cm from isocenter in a cylindrical phantom with low‐concentration background. Emission scans were acquired on a SPECT/CT system (Symbia T6, Siemens Medical Solutions) with LEHR collimation in continuous (C) and step‐and‐shoot (SS) modes for 360 views over 360° at 0.9, 1.8 and 3.6 mm/pixel. Data were iteratively reconstructed with 3D‐OSEM incorporating resolution, CT‐based attenuation, and scatter modeling, for different combinations of iterations and subsets (IT_SUB): 1_18, 10_18, 20_18, 30_18, 30_36, 30_60, 30_90. SPECT resolution was estimated using a Gaussian fit of the radial and tangential profiles through each point source. Results: TR was consistently better than RR. Anisotropy was independent of pixel size and scan mode but decreased with IT times SUB (e.g., TR/RR=0.78 and 0.62 for 1_18 and 30_90 with 0.9 mm/pixel in SS). Both TR and RR improved linearly with distance away from isocenter. The center‐to‐periphery resolution differences decreased with IT times SUB (e.g., slopes of resolution versus radius were −0.74 and −0.45 for 20_18 and 30_36 with 0.9 mm/pixel in SS) and with smaller pixel sizes (e.g., slopes of resolution versus radius were −0.89, −0.82 and −0.74 for 3.6, 1.8 and 0.9 mm/pixel for 20_18 in SS). TR and RR improved as a power‐law with IT times SUB. The rate of improvement showed no obvious dependence on pixel size. TR and RR were similar between SS and C. Conclusion: Spatial resolution of SPECT images reconstructed iteratively exhibited power‐law dependence on IT times SUB, linear dependence on radial position, and exhibited TR/RR anisotropy — modeling of which are important for accurate SPECT quantification.
AB - Purpose: To evaluate the effect of pixel size and OSEM iterative reconstruction parameters on radial (RR) and tangential (TR) Tc‐99m SPECT resolution versus distance from isocenter. Method and Materials: Ten high‐concentration Tc‐99m point sources of size <2mm3 were positioned coplanar 0–9 cm from isocenter in a cylindrical phantom with low‐concentration background. Emission scans were acquired on a SPECT/CT system (Symbia T6, Siemens Medical Solutions) with LEHR collimation in continuous (C) and step‐and‐shoot (SS) modes for 360 views over 360° at 0.9, 1.8 and 3.6 mm/pixel. Data were iteratively reconstructed with 3D‐OSEM incorporating resolution, CT‐based attenuation, and scatter modeling, for different combinations of iterations and subsets (IT_SUB): 1_18, 10_18, 20_18, 30_18, 30_36, 30_60, 30_90. SPECT resolution was estimated using a Gaussian fit of the radial and tangential profiles through each point source. Results: TR was consistently better than RR. Anisotropy was independent of pixel size and scan mode but decreased with IT times SUB (e.g., TR/RR=0.78 and 0.62 for 1_18 and 30_90 with 0.9 mm/pixel in SS). Both TR and RR improved linearly with distance away from isocenter. The center‐to‐periphery resolution differences decreased with IT times SUB (e.g., slopes of resolution versus radius were −0.74 and −0.45 for 20_18 and 30_36 with 0.9 mm/pixel in SS) and with smaller pixel sizes (e.g., slopes of resolution versus radius were −0.89, −0.82 and −0.74 for 3.6, 1.8 and 0.9 mm/pixel for 20_18 in SS). TR and RR improved as a power‐law with IT times SUB. The rate of improvement showed no obvious dependence on pixel size. TR and RR were similar between SS and C. Conclusion: Spatial resolution of SPECT images reconstructed iteratively exhibited power‐law dependence on IT times SUB, linear dependence on radial position, and exhibited TR/RR anisotropy — modeling of which are important for accurate SPECT quantification.
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U2 - 10.1118/1.3181091
DO - 10.1118/1.3181091
M3 - Article
AN - SCOPUS:85024819257
SN - 0094-2405
VL - 36
SP - 2427
JO - Medical physics
JF - Medical physics
IS - 6
ER -