18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer

Ze Qing Xu, Xiao Bei Duan, Xiao Juan Jia, Wei Fan

Research output: Contribution to journalArticle

Abstract

Objective: To explore the value of 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer (NSCLC). Methods: A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent 18F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results: Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41% (54/68), 80.65% (50/62), 80.00% (104/130), 81.82% (54/66) and 78.13% (50/64), respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42% (96/129), 86.06% (179/208), 81.60% (275/337), 76.80% (96/125) and 84.43% (179/212), respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion: 18F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.

Original languageEnglish (US)
Pages (from-to)1989-1993
Number of pages5
JournalChinese Journal of Medical Imaging Technology
Volume29
Issue number12
StatePublished - 2013

Fingerprint

Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Lymph Nodes
Neoplasm Metastasis
Sensitivity and Specificity
Research
Pathology

Keywords

  • Carcinoma, non-small-cell lung
  • Fluorodeoxyglucose F18
  • Neoplasm staging
  • Positron-emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Physiology (medical)

Cite this

18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer. / Xu, Ze Qing; Duan, Xiao Bei; Jia, Xiao Juan; Fan, Wei.

In: Chinese Journal of Medical Imaging Technology, Vol. 29, No. 12, 2013, p. 1989-1993.

Research output: Contribution to journalArticle

@article{2f8da99456214ad599791af754a69fa2,
title = "18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer",
abstract = "Objective: To explore the value of 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer (NSCLC). Methods: A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent 18F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results: Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41{\%} (54/68), 80.65{\%} (50/62), 80.00{\%} (104/130), 81.82{\%} (54/66) and 78.13{\%} (50/64), respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42{\%} (96/129), 86.06{\%} (179/208), 81.60{\%} (275/337), 76.80{\%} (96/125) and 84.43{\%} (179/212), respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion: 18F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.",
keywords = "Carcinoma, non-small-cell lung, Fluorodeoxyglucose F18, Neoplasm staging, Positron-emission tomography",
author = "Xu, {Ze Qing} and Duan, {Xiao Bei} and Jia, {Xiao Juan} and Wei Fan",
year = "2013",
language = "English (US)",
volume = "29",
pages = "1989--1993",
journal = "Chinese Journal of Medical Imaging Technology",
issn = "1003-3289",
publisher = "Editorial Board of Chinese Journal of Medical Imaging Technology",
number = "12",

}

TY - JOUR

T1 - 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer

AU - Xu, Ze Qing

AU - Duan, Xiao Bei

AU - Jia, Xiao Juan

AU - Fan, Wei

PY - 2013

Y1 - 2013

N2 - Objective: To explore the value of 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer (NSCLC). Methods: A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent 18F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results: Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41% (54/68), 80.65% (50/62), 80.00% (104/130), 81.82% (54/66) and 78.13% (50/64), respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42% (96/129), 86.06% (179/208), 81.60% (275/337), 76.80% (96/125) and 84.43% (179/212), respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion: 18F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.

AB - Objective: To explore the value of 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer (NSCLC). Methods: A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent 18F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results: Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41% (54/68), 80.65% (50/62), 80.00% (104/130), 81.82% (54/66) and 78.13% (50/64), respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42% (96/129), 86.06% (179/208), 81.60% (275/337), 76.80% (96/125) and 84.43% (179/212), respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion: 18F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.

KW - Carcinoma, non-small-cell lung

KW - Fluorodeoxyglucose F18

KW - Neoplasm staging

KW - Positron-emission tomography

UR - http://www.scopus.com/inward/record.url?scp=84895806656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895806656&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84895806656

VL - 29

SP - 1989

EP - 1993

JO - Chinese Journal of Medical Imaging Technology

JF - Chinese Journal of Medical Imaging Technology

SN - 1003-3289

IS - 12

ER -