[Survival and prognostic analysis of 221 patients with advanced laryngeal squamous cell carcinoma treated by surgery].

Tian Run Liu, An Kui Yang, Fu Jin Chen, Mu Sheng Zeng, Ming Song, Zhu Ming Guo, Wen Kuan Chen, Dian Ouyang, Qiu Li Li, Yan Feng Chen, Quan Zhang, Zong Yuan Zeng

Research output: Contribution to journalArticle

Abstract

The prognosis of advanced squamous cell carcinoma of the larynx is poor Prognostic factors of this disease vary in different studies. This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) squamous cell carcinoma (SCC) of the larynx. Clinical data of 221 patients with advanced SCC of the larynx were retrospectively analyzed. Survival analysis was performed by the life table method; comparison among/between groups was performed using the log-rank test; and multivariate analysis was carried out using the Cox proportional hazard model. The two- and five-year overall survival rates of the 221 patients were 76.9% and 51.1%; while the 2-and 5-year disease free survival rates were 60.0% and 43.0%. Patients in stage III had better prognosis than those in stage IV. Post-operative radiotherapy improved the survival rate in patients with positive surgical margins. There was no difference in the survival rate between patients underwent partial laryngectomy and those underwent total laryngectomy. Multivariate analyses indicated that age, anatomic type, post-surgical stage, surgical margin and radiotherapy influenced the disease free survival (p<0.05), whereas, age, post-surgical stage and surgical margin affected the overall survival (p<0.05). The prognosis of patients with advanced SCC of the larynx receiving surgery is poor. Age, post-surgical stage and surgical margin are the most important factors affecting the overall survival.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalAi zheng = Aizheng = Chinese journal of cancer
Volume28
Issue number3
StatePublished - Mar 1 2009

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Survival Analysis
Squamous Cell Carcinoma
Larynx
Survival Rate
Laryngectomy
Disease-Free Survival
Radiotherapy
Multivariate Analysis
Life Tables
Survival
Proportional Hazards Models
Margins of Excision

ASJC Scopus subject areas

  • Oncology

Cite this

[Survival and prognostic analysis of 221 patients with advanced laryngeal squamous cell carcinoma treated by surgery]. / Liu, Tian Run; Yang, An Kui; Chen, Fu Jin; Zeng, Mu Sheng; Song, Ming; Guo, Zhu Ming; Chen, Wen Kuan; Ouyang, Dian; Li, Qiu Li; Chen, Yan Feng; Zhang, Quan; Zeng, Zong Yuan.

In: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 28, No. 3, 01.03.2009, p. 297-302.

Research output: Contribution to journalArticle

Liu, Tian Run ; Yang, An Kui ; Chen, Fu Jin ; Zeng, Mu Sheng ; Song, Ming ; Guo, Zhu Ming ; Chen, Wen Kuan ; Ouyang, Dian ; Li, Qiu Li ; Chen, Yan Feng ; Zhang, Quan ; Zeng, Zong Yuan. / [Survival and prognostic analysis of 221 patients with advanced laryngeal squamous cell carcinoma treated by surgery]. In: Ai zheng = Aizheng = Chinese journal of cancer. 2009 ; Vol. 28, No. 3. pp. 297-302.
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abstract = "The prognosis of advanced squamous cell carcinoma of the larynx is poor Prognostic factors of this disease vary in different studies. This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) squamous cell carcinoma (SCC) of the larynx. Clinical data of 221 patients with advanced SCC of the larynx were retrospectively analyzed. Survival analysis was performed by the life table method; comparison among/between groups was performed using the log-rank test; and multivariate analysis was carried out using the Cox proportional hazard model. The two- and five-year overall survival rates of the 221 patients were 76.9{\%} and 51.1{\%}; while the 2-and 5-year disease free survival rates were 60.0{\%} and 43.0{\%}. Patients in stage III had better prognosis than those in stage IV. Post-operative radiotherapy improved the survival rate in patients with positive surgical margins. There was no difference in the survival rate between patients underwent partial laryngectomy and those underwent total laryngectomy. Multivariate analyses indicated that age, anatomic type, post-surgical stage, surgical margin and radiotherapy influenced the disease free survival (p<0.05), whereas, age, post-surgical stage and surgical margin affected the overall survival (p<0.05). The prognosis of patients with advanced SCC of the larynx receiving surgery is poor. Age, post-surgical stage and surgical margin are the most important factors affecting the overall survival.",
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