TY - JOUR
T1 - Survival rates in T1 and T2 gastric cancer
T2 - A Western report
AU - Ikoma, Naruhiko
AU - Blum, Mariela
AU - Chiang, Yi Ju
AU - Estrella, Jeannelyn S.
AU - Roy-Chowdhuri, Sinchita
AU - Fournier, Keith
AU - Mansfield, Paul
AU - Ajani, Jaffer A.
AU - Badgwell, Brian D.
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background and Objectives: The purpose of this study was to identify clinicopathologic factors associated with overall survival (OS) in early T stage gastric cancer in a Western population. Methods: Patients with stage T1 or T2 gastric or gastroesophageal adenocarcinoma who had undergone upfront gastrectomy from 1995 to 2013 were identified in an institutional database. Results: We identified 121 patients with pathologic stage T1 or T2 tumors (49 [41%] T1a; 49 [41%] T1b; and 23 [19%] T2) who underwent R0 resection without preoperative treatment. Of these, 53% were white, 9% African American, 17% Hispanic, and 22% Asian. The median follow-up was 5.7 years, and the 5-year OS rate was 89% (98%, 93%, and 66% for patients with T1a, T1b, and T2 tumors, respectively). Univariate analysis revealed a higher risk of death in patients with T2 tumors and those of African American race. On multivariate analysis, T2 stage was the only variable independently associated with OS (hazard ratio, 2.80; 95% confidence interval, 1.11–7.12; P = 0.03). Conclusion: In this study of a Western population of patients with T1 or T2 gastric cancer, T2 stage was associated with diminished OS, whereas nodal status and race were not. J. Surg. Oncol. 2016;114:602–606.
AB - Background and Objectives: The purpose of this study was to identify clinicopathologic factors associated with overall survival (OS) in early T stage gastric cancer in a Western population. Methods: Patients with stage T1 or T2 gastric or gastroesophageal adenocarcinoma who had undergone upfront gastrectomy from 1995 to 2013 were identified in an institutional database. Results: We identified 121 patients with pathologic stage T1 or T2 tumors (49 [41%] T1a; 49 [41%] T1b; and 23 [19%] T2) who underwent R0 resection without preoperative treatment. Of these, 53% were white, 9% African American, 17% Hispanic, and 22% Asian. The median follow-up was 5.7 years, and the 5-year OS rate was 89% (98%, 93%, and 66% for patients with T1a, T1b, and T2 tumors, respectively). Univariate analysis revealed a higher risk of death in patients with T2 tumors and those of African American race. On multivariate analysis, T2 stage was the only variable independently associated with OS (hazard ratio, 2.80; 95% confidence interval, 1.11–7.12; P = 0.03). Conclusion: In this study of a Western population of patients with T1 or T2 gastric cancer, T2 stage was associated with diminished OS, whereas nodal status and race were not. J. Surg. Oncol. 2016;114:602–606.
KW - gastric cancer
KW - race
KW - survival
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U2 - 10.1002/jso.24382
DO - 10.1002/jso.24382
M3 - Article
C2 - 27439746
AN - SCOPUS:84992159149
SN - 0022-4790
VL - 114
SP - 602
EP - 606
JO - Journal of surgical oncology
JF - Journal of surgical oncology
IS - 5
ER -