Survival study and treatment strategy for second primary tumors in the oral cavity in patients with nasopharyngeal carcinoma after definitive radiation

Ming Song, Shi Min Zhuang, Shu Wei Chen, Quan Zhang, An Kui Yang, Li Ping Wang, Zhu Ming Guo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. The purpose of this study was to investigate the clinicopathologic characteristics and prognostic factors of second primary tumors (SPTs) in the oral cavity in patients with nasopharyngeal carcinoma (NPC) after definitive radiation, and to determine an optimal treatment strategy for these patients. Methods. This retrospective study enrolled consecutive patients who were admitted to the Sun Yat-Sen University Cancer Center between 1990 and 2005. Results. The key prognostic factors influencing the survival were age when NPC was diagnosed, TNM stage, and surgery treatment modality. Multivariate analysis revealed that the clinical TNM stage was an independent risk factor for patient survival. Conclusion. Clinical TNM stage was an independent prognostic factor that influenced the treatment outcome. Our data indicate that the survival of patients with SPTs in the oral cavity can be improved by modifying treatment strategy, and that surgery is preferred when SPTs are diagnosed at an earlier stage.

Original languageEnglish (US)
Pages (from-to)1551-1555
Number of pages5
JournalHead and Neck
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2012

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Mouth
Radiation
Survival
Neoplasms
Therapeutics
Solar System
Multivariate Analysis
Retrospective Studies
Nasopharyngeal carcinoma

Keywords

  • definitive radiation
  • nasopharyngeal carcinoma
  • oral tumors
  • second primary tumors
  • treatment strategy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Survival study and treatment strategy for second primary tumors in the oral cavity in patients with nasopharyngeal carcinoma after definitive radiation. / Song, Ming; Zhuang, Shi Min; Chen, Shu Wei; Zhang, Quan; Yang, An Kui; Wang, Li Ping; Guo, Zhu Ming.

In: Head and Neck, Vol. 34, No. 11, 01.11.2012, p. 1551-1555.

Research output: Contribution to journalArticle

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AU - Zhuang, Shi Min

AU - Chen, Shu Wei

AU - Zhang, Quan

AU - Yang, An Kui

AU - Wang, Li Ping

AU - Guo, Zhu Ming

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N2 - Background. The purpose of this study was to investigate the clinicopathologic characteristics and prognostic factors of second primary tumors (SPTs) in the oral cavity in patients with nasopharyngeal carcinoma (NPC) after definitive radiation, and to determine an optimal treatment strategy for these patients. Methods. This retrospective study enrolled consecutive patients who were admitted to the Sun Yat-Sen University Cancer Center between 1990 and 2005. Results. The key prognostic factors influencing the survival were age when NPC was diagnosed, TNM stage, and surgery treatment modality. Multivariate analysis revealed that the clinical TNM stage was an independent risk factor for patient survival. Conclusion. Clinical TNM stage was an independent prognostic factor that influenced the treatment outcome. Our data indicate that the survival of patients with SPTs in the oral cavity can be improved by modifying treatment strategy, and that surgery is preferred when SPTs are diagnosed at an earlier stage.

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