Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity

Dong Sik Jung; Frank P. Tverdek; Dimitrios P. Kontoyiannis

doi:10.1128/AAC.04035-14

Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity

Dong Sik Jung
, Frank P. Tverdek
, Dimitrios P. Kontoyiannis

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

We evaluated posaconazole serum concentrations and hepatotoxicity in 12 leukemia patients who transitioned from posaconazole suspension to tablets. Patients who switched to tablets had significantly increased posaconazole concentrations (median: suspension, 748 ng/ml; tablet, 1,910 ng/ml; P<0.01) without clinically relevant hepatotoxicity.

Original language	English (US)
Pages (from-to)	6993-6995
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	11
DOIs	https://doi.org/10.1128/AAC.04035-14
State	Published - Nov 1 2014

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.04035-14

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title = "Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity",

abstract = "We evaluated posaconazole serum concentrations and hepatotoxicity in 12 leukemia patients who transitioned from posaconazole suspension to tablets. Patients who switched to tablets had significantly increased posaconazole concentrations (median: suspension, 748 ng/ml; tablet, 1,910 ng/ml; P<0.01) without clinically relevant hepatotoxicity.",

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AB - We evaluated posaconazole serum concentrations and hepatotoxicity in 12 leukemia patients who transitioned from posaconazole suspension to tablets. Patients who switched to tablets had significantly increased posaconazole concentrations (median: suspension, 748 ng/ml; tablet, 1,910 ng/ml; P<0.01) without clinically relevant hepatotoxicity.

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Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity

Abstract

ASJC Scopus subject areas

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