TY - JOUR
T1 - Sympathetic nervous system regulation of the tumour microenvironment
AU - Cole, Steven W.
AU - Nagaraja, Archana S.
AU - Lutgendorf, Susan K.
AU - Green, Paige A.
AU - Sood, Anil K.
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited.
PY - 2015/9/25
Y1 - 2015/9/25
N2 - The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.
AB - The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.
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U2 - 10.1038/nrc3978
DO - 10.1038/nrc3978
M3 - Review article
C2 - 26299593
AN - SCOPUS:84940028564
SN - 1474-175X
VL - 15
SP - 563
EP - 572
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 9
ER -