Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

Marc El Beaino; Dejka M. Araujo; Alexander J. Lazar; Patrick P. Lin

doi:10.1245/s10434-017-5855-x

Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

Marc El Beaino, Dejka M. Araujo, Alexander J. Lazar, Patrick P. Lin

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.

Original language	English (US)
Pages (from-to)	2145-2154
Number of pages	10
Journal	Annals of surgical oncology
Volume	24
Issue number	8
DOIs	https://doi.org/10.1245/s10434-017-5855-x
State	Published - Aug 1 2017

ASJC Scopus subject areas

Surgery
Oncology

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title = "Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy",

abstract = "Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.",

author = "{El Beaino}, Marc and Araujo, {Dejka M.} and Lazar, {Alexander J.} and Lin, {Patrick P.}",

note = "Funding Information: We acknowledge Kim-Anh Vu for graphic art assistance and the Amschwand Sarcoma Cancer Foundation for support. Publisher Copyright: {\textcopyright} 2017, Society of Surgical Oncology.",

year = "2017",

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doi = "10.1245/s10434-017-5855-x",

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T1 - Synovial Sarcoma

T2 - Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

AU - El Beaino, Marc

AU - Araujo, Dejka M.

AU - Lazar, Alexander J.

AU - Lin, Patrick P.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.

AB - Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.

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JO - Annals of surgical oncology

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Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

Abstract

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