Synthesis and antimicrobial activity of novel oxysterols from lanosterol

Bapurao B. Shingate; Braja G. Hazra; Deepak B. Salunke; Vandana S. Pore; Fazal Shirazi; Mukund V. Deshpande

doi:10.1016/j.tet.2013.10.090

Synthesis and antimicrobial activity of novel oxysterols from lanosterol

Bapurao B. Shingate
, Braja G. Hazra
, Deepak B. Salunke
, Vandana S. Pore
, Fazal Shirazi
, Mukund V. Deshpande

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Chemically diverse oxysterols and their synthetic manipulations were carried out from variety of Δ⁸⁽⁹⁾-lanosterol derivatives and evaluated for their in vitro antimicrobial activities. Most of the synthesized oxysterols exhibited significant antifungal activity against the tested strains.

Original language	English (US)
Pages (from-to)	11155-11163
Number of pages	9
Journal	Tetrahedron
Volume	69
Issue number	52
DOIs	https://doi.org/10.1016/j.tet.2013.10.090
State	Published - Dec 30 2013
Externally published	Yes

Keywords

Allylic oxidation
Antibacterial activity
Antifungal activity
Dihydroxylation
Oxygenated steroids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tet.2013.10.090

Cite this

@article{0629729c8523434babb515f16ca3c7de,

title = "Synthesis and antimicrobial activity of novel oxysterols from lanosterol",

abstract = "Chemically diverse oxysterols and their synthetic manipulations were carried out from variety of Δ8(9)-lanosterol derivatives and evaluated for their in vitro antimicrobial activities. Most of the synthesized oxysterols exhibited significant antifungal activity against the tested strains.",

keywords = "Allylic oxidation, Antibacterial activity, Antifungal activity, Dihydroxylation, Oxygenated steroids",

author = "Shingate, \{Bapurao B.\} and Hazra, \{Braja G.\} and Salunke, \{Deepak B.\} and Pore, \{Vandana S.\} and Fazal Shirazi and Deshpande, \{Mukund V.\}",

note = "Funding Information: B.B.S. thanks the University Grants Commission, New Delhi and B.G.H. to the Council of Scientific and Industrial Research, New Delhi , for financial assistance. ",

year = "2013",

month = dec,

day = "30",

doi = "10.1016/j.tet.2013.10.090",

language = "English (US)",

volume = "69",

pages = "11155--11163",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "52",

}

TY - JOUR

T1 - Synthesis and antimicrobial activity of novel oxysterols from lanosterol

AU - Shingate, Bapurao B.

AU - Hazra, Braja G.

AU - Salunke, Deepak B.

AU - Pore, Vandana S.

AU - Shirazi, Fazal

AU - Deshpande, Mukund V.

N1 - Funding Information: B.B.S. thanks the University Grants Commission, New Delhi and B.G.H. to the Council of Scientific and Industrial Research, New Delhi , for financial assistance.

PY - 2013/12/30

Y1 - 2013/12/30

N2 - Chemically diverse oxysterols and their synthetic manipulations were carried out from variety of Δ8(9)-lanosterol derivatives and evaluated for their in vitro antimicrobial activities. Most of the synthesized oxysterols exhibited significant antifungal activity against the tested strains.

AB - Chemically diverse oxysterols and their synthetic manipulations were carried out from variety of Δ8(9)-lanosterol derivatives and evaluated for their in vitro antimicrobial activities. Most of the synthesized oxysterols exhibited significant antifungal activity against the tested strains.

KW - Allylic oxidation

KW - Antibacterial activity

KW - Antifungal activity

KW - Dihydroxylation

KW - Oxygenated steroids

UR - https://www.scopus.com/pages/publications/84889577200

UR - https://www.scopus.com/pages/publications/84889577200#tab=citedBy

U2 - 10.1016/j.tet.2013.10.090

DO - 10.1016/j.tet.2013.10.090

M3 - Article

AN - SCOPUS:84889577200

SN - 0040-4020

VL - 69

SP - 11155

EP - 11163

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -

Synthesis and antimicrobial activity of novel oxysterols from lanosterol

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this