Synthesis and characterization of a series of hydrophobic antitumor amine platinum(II) carboxylates

Abdul R. Khokhar; Quanyun Xu

doi:10.1080/00958979009408207

Synthesis and characterization of a series of hydrophobic antitumor amine platinum(II) carboxylates

Abdul R. Khokhar, Quanyun Xu

Institute for Applied Cancer Science (IACS)

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

As part of a systematic study, a series of hydrophobic amine platinum(II) carboxylate complexes has been prepared as potential antitumor agents in a liposomal-entrapped form. These complexes have been characterized by elemental analysis, IR, ¹³C and ¹⁹⁵Pt NMR spectroscopic techniques. Effect of ligand donors on NMR chemical shift is briefly discussed.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Journal of Coordination Chemistry
Volume	22
Issue number	1
DOIs	https://doi.org/10.1080/00958979009408207
State	Published - Oct 1 1990

Keywords

Platinum
amine
carboxylate
hydrophobicity
synthesis

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry

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10.1080/00958979009408207

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title = "Synthesis and characterization of a series of hydrophobic antitumor amine platinum(II) carboxylates",

abstract = "As part of a systematic study, a series of hydrophobic amine platinum(II) carboxylate complexes has been prepared as potential antitumor agents in a liposomal-entrapped form. These complexes have been characterized by elemental analysis, IR, 13C and 195Pt NMR spectroscopic techniques. Effect of ligand donors on NMR chemical shift is briefly discussed.",

keywords = "Platinum, amine, carboxylate, hydrophobicity, synthesis",

author = "Khokhar, {Abdul R.} and Quanyun Xu",

note = "Funding Information: This work was supported by grant CA41581 from the National Cancer Institute to ARK. We are grateful to Michael Costigan for technical assistance.",

year = "1990",

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T1 - Synthesis and characterization of a series of hydrophobic antitumor amine platinum(II) carboxylates

AU - Khokhar, Abdul R.

AU - Xu, Quanyun

N1 - Funding Information: This work was supported by grant CA41581 from the National Cancer Institute to ARK. We are grateful to Michael Costigan for technical assistance.

PY - 1990/10/1

Y1 - 1990/10/1

N2 - As part of a systematic study, a series of hydrophobic amine platinum(II) carboxylate complexes has been prepared as potential antitumor agents in a liposomal-entrapped form. These complexes have been characterized by elemental analysis, IR, 13C and 195Pt NMR spectroscopic techniques. Effect of ligand donors on NMR chemical shift is briefly discussed.

AB - As part of a systematic study, a series of hydrophobic amine platinum(II) carboxylate complexes has been prepared as potential antitumor agents in a liposomal-entrapped form. These complexes have been characterized by elemental analysis, IR, 13C and 195Pt NMR spectroscopic techniques. Effect of ligand donors on NMR chemical shift is briefly discussed.

KW - Platinum

KW - amine

KW - carboxylate

KW - hydrophobicity

KW - synthesis

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IS - 1

ER -

Synthesis and characterization of a series of hydrophobic antitumor amine platinum(II) carboxylates

Abstract

Keywords

ASJC Scopus subject areas

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