Abstract
An α-galactosyl ceramide (α-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKT-cell proliferation and elicit T-helper cytokines, IL-4 and IFNγ. Compound 2 combines the acyl chain of the potent, Th2 biasing α-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related α-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison.
Original language | English (US) |
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Pages (from-to) | 3386-3388 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 2009 |
Externally published | Yes |
Keywords
- Alpha-galactosyl ceramides
- CD1d
- Glycolipids
- iNKT cell stimulation
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry