TY - JOUR
T1 - Tamoxifen as an anti tumour agent
T2 - effect on oestrogen binding
AU - Jordan, V. C.
AU - Dowse, L. J.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1976
Y1 - 1976
N2 - Tamoxifen (ICI 46,474) has been shown to possess anti tumor properties in the dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinoma model. During tamoxifen therapy the binding of [3H]oestradiol in vivo to uterine (P <0.001), vaginal (P <0.01) and tumor (P <0.001) tissues was significantly reduced. Tamoxifen therapy was without effect on the binding of [3H]oestradiol in heart tissue. The determination of specific oestrogen binding components in vitro was significantly reduced (P <0.01) in tumors from tamoxifen treated rats and tamoxifen inhibited the binding of [3H]oestradiol to 8S oestrogen binding compogents, derived from rat uteri and DMBA induced tumors, in vitro.
AB - Tamoxifen (ICI 46,474) has been shown to possess anti tumor properties in the dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinoma model. During tamoxifen therapy the binding of [3H]oestradiol in vivo to uterine (P <0.001), vaginal (P <0.01) and tumor (P <0.001) tissues was significantly reduced. Tamoxifen therapy was without effect on the binding of [3H]oestradiol in heart tissue. The determination of specific oestrogen binding components in vitro was significantly reduced (P <0.01) in tumors from tamoxifen treated rats and tamoxifen inhibited the binding of [3H]oestradiol to 8S oestrogen binding compogents, derived from rat uteri and DMBA induced tumors, in vitro.
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U2 - 10.1677/joe.0.0680297
DO - 10.1677/joe.0.0680297
M3 - Article
C2 - 176295
AN - SCOPUS:0017152984
SN - 0022-0795
VL - 68
SP - 297
EP - 303
JO - Journal of Endocrinology
JF - Journal of Endocrinology
IS - 2
ER -