Targeted Therapy in Solid Tumors: Sarcomas

Sarcomas represent a heterogeneous group of mesenchymal tumors affecting soft tissues and bone. Despite the use of chemotherapy for treatment of advanced/metastatic disease, many patients still die of metastases as a result of acquired resistance to existing therapies or due to the absence of any effective treatment modalities. Strategies that target specific signaling pathways may improve our ability to help sarcoma patients. A review of signaling pathways for which targeted therapies have altered our management of sarcomas is provided to understand our treatment strategies and to provide insight into the future management of these rare malignancies.