Targeting cancer cell mitochondria as a therapeutic approach

Shijun Wen, Daqian Zhu, Peng Huang

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Mitochondria are double membrane-enveloped organelles that play a central role in cellular metabolism, calcium homeostasis, redox signaling and cell fates. They function as main generators of ATP, metabolites for the construction of macromolecules and reactive oxygen species. In many cancer cells, mitochondria seem dysfunctional, manifested by a shift of energy metabolism from oxidative phosphorylation to active glycolysis and an increase in reactive oxygen species generation. These metabolic changes are often associated with upregulation of NAD(P)H oxidase. Importantly, the metabolic reprogramming in a cancer cell is mechanistically linked to oncogenic signals. Targeting mitochondria as a cancer therapeutic strategy has attracted much attention in the recent years and multiple review articles in this area have been published. This article attempts to provide an update on recent progress in identification of mitochondria-Associated molecules as potential anticancer targets and the respective targeting compounds.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalFuture Medicinal Chemistry
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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