Targeting deubiquitinases in CLL

Deepa Sampath

doi:10.1182/blood-2017-06-786236

Targeting deubiquitinases in CLL

Deepa Sampath

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.¹

Original language	English (US)
Pages (from-to)	100-101
Number of pages	2
Journal	Blood
Volume	130
Issue number	2
DOIs	https://doi.org/10.1182/blood-2017-06-786236
State	Published - Jul 13 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "Targeting deubiquitinases in CLL",

abstract = "In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.1",

author = "Deepa Sampath",

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doi = "10.1182/blood-2017-06-786236",

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AB - In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.1

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DO - 10.1182/blood-2017-06-786236

M3 - Comment/debate

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Targeting deubiquitinases in CLL

Abstract

ASJC Scopus subject areas

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