Targeting lammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals

Bharat B Aggarwal

Research output: Contribution to journalReview article

250 Citations (Scopus)

Abstract

Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a prolammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-lammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it presses the prolammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-Wnt/β and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.

Original languageEnglish (US)
Pages (from-to)173-199
Number of pages27
JournalAnnual Review of Nutrition
Volume30
DOIs
StatePublished - Aug 21 2010

Fingerprint

Curcumin
Metabolic Diseases
Dietary Supplements
Obesity
Spices
Insulin Resistance
Piper nigrum
Cinnamomum zeylanicum
Resistin
Syzygium
Ginger
Curcuma
Catenins
STAT3 Transcription Factor
Hepatic Stellate Cells
Peroxisome Proliferator-Activated Receptors
Adipokines
NF-kappa B
Chemokine CCL2
Adiponectin

Keywords

  • NF-κB
  • cancer
  • curcumin
  • diabetes
  • inflammation
  • insulin
  • nutraceuticals
  • obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Targeting lammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. / Aggarwal, Bharat B.

In: Annual Review of Nutrition, Vol. 30, 21.08.2010, p. 173-199.

Research output: Contribution to journalReview article

@article{46533c882c174cb2a7ff68748c859172,
title = "Targeting lammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals",
abstract = "Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a prolammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-lammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it presses the prolammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-Wnt/β and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.",
keywords = "NF-κB, cancer, curcumin, diabetes, inflammation, insulin, nutraceuticals, obesity",
author = "Aggarwal, {Bharat B}",
year = "2010",
month = "8",
day = "21",
doi = "10.1146/annurev.nutr.012809.104755",
language = "English (US)",
volume = "30",
pages = "173--199",
journal = "Annual Review of Nutrition",
issn = "0199-9885",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Targeting lammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals

AU - Aggarwal, Bharat B

PY - 2010/8/21

Y1 - 2010/8/21

N2 - Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a prolammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-lammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it presses the prolammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-Wnt/β and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.

AB - Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a prolammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-lammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it presses the prolammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-Wnt/β and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.

KW - NF-κB

KW - cancer

KW - curcumin

KW - diabetes

KW - inflammation

KW - insulin

KW - nutraceuticals

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=77955633792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955633792&partnerID=8YFLogxK

U2 - 10.1146/annurev.nutr.012809.104755

DO - 10.1146/annurev.nutr.012809.104755

M3 - Review article

VL - 30

SP - 173

EP - 199

JO - Annual Review of Nutrition

JF - Annual Review of Nutrition

SN - 0199-9885

ER -