TY - JOUR
T1 - Targeting MicroRNAs with small molecules
T2 - From dream to reality
AU - Zhang, S.
AU - Chen, L.
AU - Jung, E. J.
AU - Calin, G. A.
PY - 2010/6
Y1 - 2010/6
N2 - Currently, one out of four deaths in the United States is due to cancer; therefore, every major therapeutic advance in cancer has the potential to save many lives. One of the most fascinating discoveries in the area of molecular oncology in the past decade is that, in cancer, alterations in both protein-coding genes and noncoding RNAs, known as microRNAs (miRNAs), complement each other. In this article, we focus on a novel idea involving the use of small molecules to target overexpressed miRNAs as a new therapy for diseases, particularly cancer, in humans.
AB - Currently, one out of four deaths in the United States is due to cancer; therefore, every major therapeutic advance in cancer has the potential to save many lives. One of the most fascinating discoveries in the area of molecular oncology in the past decade is that, in cancer, alterations in both protein-coding genes and noncoding RNAs, known as microRNAs (miRNAs), complement each other. In this article, we focus on a novel idea involving the use of small molecules to target overexpressed miRNAs as a new therapy for diseases, particularly cancer, in humans.
UR - http://www.scopus.com/inward/record.url?scp=77952584924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952584924&partnerID=8YFLogxK
U2 - 10.1038/clpt.2010.46
DO - 10.1038/clpt.2010.46
M3 - Review article
C2 - 20428111
AN - SCOPUS:77952584924
SN - 0009-9236
VL - 87
SP - 754
EP - 758
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 6
ER -