Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer

W. Zhou; S. Dai; H. Zhu; Z. Song; Y. Cai; J. B. Lee; Z. Li; X. Hu; B. Fang; C. He; X. Huang

doi:10.1038/gt.2017.2

Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer

W. Zhou, S. Dai, H. Zhu, Z. Song, Y. Cai, J. B. Lee, Z. Li, X. Hu, B. Fang, C. He, X. Huang

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Peritoneal dissemination is the most common condition of metastasis in gastric cancer. The survival duration of a patient with advanced stage gastric cancer, may be improved by gene therapy. In this study, we used an oncolytic adenovirus vector (Ad/TRAIL-E1) that expresses both the TRAIL and E1A genes under the control of a tumor-specific promoter. We evaluated the anti-tumor effect of Ad/TRAIL-E1 on gastric cancer cells in vitro, as well as in vivo in a xenograft peritoneal carcinomatosis mouse model. Our data showed that Ad/TRAIL-E1 induced TRAIL-mediated apoptosis in gastric cancer cell lines, but not in the normal cell lines. In addition, Ad/TRAIL-E1 significantly inhibited peritoneal metastasis and prolonged the survival of mice without treatment-related toxicity. Therefore, tumor-specific TRAIL expression from an oncolytic adenovirus vector may provide a novel therapeutic approach for the treatment of advance stage gastric cancer with peritoneal dissemination.

Original language	English (US)
Pages (from-to)	199-207
Number of pages	9
Journal	Gene Therapy
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/gt.2017.2
State	Published - Apr 1 2017
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics

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title = "Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer",

abstract = "Peritoneal dissemination is the most common condition of metastasis in gastric cancer. The survival duration of a patient with advanced stage gastric cancer, may be improved by gene therapy. In this study, we used an oncolytic adenovirus vector (Ad/TRAIL-E1) that expresses both the TRAIL and E1A genes under the control of a tumor-specific promoter. We evaluated the anti-tumor effect of Ad/TRAIL-E1 on gastric cancer cells in vitro, as well as in vivo in a xenograft peritoneal carcinomatosis mouse model. Our data showed that Ad/TRAIL-E1 induced TRAIL-mediated apoptosis in gastric cancer cell lines, but not in the normal cell lines. In addition, Ad/TRAIL-E1 significantly inhibited peritoneal metastasis and prolonged the survival of mice without treatment-related toxicity. Therefore, tumor-specific TRAIL expression from an oncolytic adenovirus vector may provide a novel therapeutic approach for the treatment of advance stage gastric cancer with peritoneal dissemination.",

author = "W. Zhou and S. Dai and H. Zhu and Z. Song and Y. Cai and Lee, {J. B.} and Z. Li and X. Hu and B. Fang and C. He and X. Huang",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China grant 81402580, 81370461 and 81272681. Publisher Copyright: {\textcopyright} 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",

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AU - Zhou, W.

AU - Dai, S.

AU - Zhu, H.

AU - Song, Z.

AU - Cai, Y.

AU - Lee, J. B.

AU - Li, Z.

AU - Hu, X.

AU - Fang, B.

AU - He, C.

AU - Huang, X.

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China grant 81402580, 81370461 and 81272681. Publisher Copyright: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Peritoneal dissemination is the most common condition of metastasis in gastric cancer. The survival duration of a patient with advanced stage gastric cancer, may be improved by gene therapy. In this study, we used an oncolytic adenovirus vector (Ad/TRAIL-E1) that expresses both the TRAIL and E1A genes under the control of a tumor-specific promoter. We evaluated the anti-tumor effect of Ad/TRAIL-E1 on gastric cancer cells in vitro, as well as in vivo in a xenograft peritoneal carcinomatosis mouse model. Our data showed that Ad/TRAIL-E1 induced TRAIL-mediated apoptosis in gastric cancer cell lines, but not in the normal cell lines. In addition, Ad/TRAIL-E1 significantly inhibited peritoneal metastasis and prolonged the survival of mice without treatment-related toxicity. Therefore, tumor-specific TRAIL expression from an oncolytic adenovirus vector may provide a novel therapeutic approach for the treatment of advance stage gastric cancer with peritoneal dissemination.

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Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer

Abstract

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