The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence

Juan P. Cata; Megan L. Uhelski; Aysegul Gorur; Siddhant Bhoir; Nisa Ilsin; Patrick M. Dougherty

doi:10.1002/adbi.202200020

The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence

Juan P. Cata, Megan L. Uhelski, Aysegul Gorur, Siddhant Bhoir, Nisa Ilsin, Patrick M. Dougherty

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has increased and, thus, cancer-related sequela. Pain affects the life of patients with cancer and survivors. Prescription opioids continue as the analgesic of choice to treat moderate-to-severe cancer-related pain. There has been controversy on whether opioids impact cancer progression by acting on cancer cells or the tumor microenvironment. The μ-opioid receptor is the site of action of prescription opioids. This receptor can participate in an important mechanism of cancer spread, such as perineural invasion. In this review, current evidence on the role of the μ-opioid receptor in cancer growth is summarized and preliminary evidence about its effect on the cross-talk between sensory neurons and malignant cells is provided.

Original language	English (US)
Journal	Advanced Biology
DOIs	https://doi.org/10.1002/adbi.202200020
State	Published - Sep 2022

Keywords

cancer progression
opioids
perineural invasion
µ-opioid receptor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Biomedical Engineering
Biomaterials

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10.1002/adbi.202200020

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title = "The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence",

abstract = "Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has increased and, thus, cancer-related sequela. Pain affects the life of patients with cancer and survivors. Prescription opioids continue as the analgesic of choice to treat moderate-to-severe cancer-related pain. There has been controversy on whether opioids impact cancer progression by acting on cancer cells or the tumor microenvironment. The μ-opioid receptor is the site of action of prescription opioids. This receptor can participate in an important mechanism of cancer spread, such as perineural invasion. In this review, current evidence on the role of the μ-opioid receptor in cancer growth is summarized and preliminary evidence about its effect on the cross-talk between sensory neurons and malignant cells is provided.",

keywords = "cancer progression, opioids, perineural invasion, µ-opioid receptor",

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language = "English (US)",

journal = "Advanced Biology",

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T2 - A Short Review and New Evidence

AU - Cata, Juan P.

AU - Uhelski, Megan L.

AU - Gorur, Aysegul

AU - Bhoir, Siddhant

AU - Ilsin, Nisa

AU - Dougherty, Patrick M.

PY - 2022/9

Y1 - 2022/9

N2 - Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has increased and, thus, cancer-related sequela. Pain affects the life of patients with cancer and survivors. Prescription opioids continue as the analgesic of choice to treat moderate-to-severe cancer-related pain. There has been controversy on whether opioids impact cancer progression by acting on cancer cells or the tumor microenvironment. The μ-opioid receptor is the site of action of prescription opioids. This receptor can participate in an important mechanism of cancer spread, such as perineural invasion. In this review, current evidence on the role of the μ-opioid receptor in cancer growth is summarized and preliminary evidence about its effect on the cross-talk between sensory neurons and malignant cells is provided.

AB - Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has increased and, thus, cancer-related sequela. Pain affects the life of patients with cancer and survivors. Prescription opioids continue as the analgesic of choice to treat moderate-to-severe cancer-related pain. There has been controversy on whether opioids impact cancer progression by acting on cancer cells or the tumor microenvironment. The μ-opioid receptor is the site of action of prescription opioids. This receptor can participate in an important mechanism of cancer spread, such as perineural invasion. In this review, current evidence on the role of the μ-opioid receptor in cancer growth is summarized and preliminary evidence about its effect on the cross-talk between sensory neurons and malignant cells is provided.

KW - cancer progression

KW - opioids

KW - perineural invasion

KW - µ-opioid receptor

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The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence

Abstract

Keywords

ASJC Scopus subject areas

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