TY - JOUR
T1 - The BATTLE to personalize lung cancer prevention through reverse migration
AU - Gold, Kathryn A.
AU - Kim, Edward S.
AU - Lee, J. Jack
AU - Wistuba, Ignacio I.
AU - Farhangfar, Carol J.
AU - Hong, Waun Ki
PY - 2011/7
Y1 - 2011/7
N2 - Agents can enter clinical development for cancer prevention either initially or after previous development for a different indication, such as arthritis, with both approaches consuming many years of development before an agent is fully evaluated for cancer prevention. We propose the following, third approach: reverse migration, that is, importing agents, targets, and study designs to personalize interventions and concepts developed in advanced cancer to the setting of cancer prevention. Importing these "ready-made" features from therapy will allow reverse migration to streamline preventive agent development. We recently reported the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial of personalized lung cancer therapy and now propose the reverse migration development of personalized lung cancer prevention based on the BATTLE model.
AB - Agents can enter clinical development for cancer prevention either initially or after previous development for a different indication, such as arthritis, with both approaches consuming many years of development before an agent is fully evaluated for cancer prevention. We propose the following, third approach: reverse migration, that is, importing agents, targets, and study designs to personalize interventions and concepts developed in advanced cancer to the setting of cancer prevention. Importing these "ready-made" features from therapy will allow reverse migration to streamline preventive agent development. We recently reported the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial of personalized lung cancer therapy and now propose the reverse migration development of personalized lung cancer prevention based on the BATTLE model.
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U2 - 10.1158/1940-6207.CAPR-11-0232
DO - 10.1158/1940-6207.CAPR-11-0232
M3 - Comment/debate
C2 - 21733820
AN - SCOPUS:79957874894
SN - 1940-6207
VL - 4
SP - 962
EP - 972
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 7
ER -