TY - JOUR
T1 - The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation
AU - Settle, Stephen
AU - Marker, Paul
AU - Gurley, Kyle
AU - Sinha, Abhishek
AU - Thacker, Abigail
AU - Wang, Yuzhuo
AU - Higgins, Kay
AU - Cunha, Gerald
AU - Kingsley, David M.
N1 - Funding Information:
We thank Janet Rossant, Andras Nagy for R1 cells, Yugi-Mishina for the Bmpr1a probe, Vicki Rosen for recombinant GDF7 protein, Ken Ohgi for technical assistance with probes and plasmids, and members of the Kingsley lab for useful comments on the manuscript. This work was supported by a postdoctoral fellowship from the American Cancer Society, PF-98-153-01 (to P.C.M.), and by National Institutes of Health Grants CA59831-07, CA64872-06, DK47517-06, and DK52708-03 (to G.R.C.); and AR42236-07 (to D.M.K.). D.M.K. is an assistant investigator of the Howard Hughes Medical Institute.
PY - 2001/6/1
Y1 - 2001/6/1
N2 - Epithelial-mesenchymal interactions play an important role in the development of many different organs and tissues. The secretory glands of the male reproductive system, including the prostate and seminal vesicles, are derived from epithelial precursors. Signals from the underlying mesenchyme are required for normal growth, branching, and differentiation of the seminal vesicle epithelium. Here, we show that a member of the BMP family, Gdf7, is required for normal seminal vesicle development. Expression and tissue recombination experiments suggest that Gdf7 is a mesenchymal signal that acts in a paracrine fashion to control the differentiation of the seminal vesicle epithelium.
AB - Epithelial-mesenchymal interactions play an important role in the development of many different organs and tissues. The secretory glands of the male reproductive system, including the prostate and seminal vesicles, are derived from epithelial precursors. Signals from the underlying mesenchyme are required for normal growth, branching, and differentiation of the seminal vesicle epithelium. Here, we show that a member of the BMP family, Gdf7, is required for normal seminal vesicle development. Expression and tissue recombination experiments suggest that Gdf7 is a mesenchymal signal that acts in a paracrine fashion to control the differentiation of the seminal vesicle epithelium.
UR - https://www.scopus.com/pages/publications/0343337332
UR - https://www.scopus.com/pages/publications/0343337332#tab=citedBy
U2 - 10.1006/dbio.2001.0244
DO - 10.1006/dbio.2001.0244
M3 - Article
C2 - 11356025
AN - SCOPUS:0343337332
SN - 0012-1606
VL - 234
SP - 138
EP - 150
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -