The bone marrow microenvironment and its impact in acute and chronic B cell malignancies

Jan Andreas Burger, Dorothy A. Sipkins

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The bone marrow (BM) hosts normal hematopoiesis by providing the cellular and molecular environment necessary for hematopoietic stem cell maintenance, expansion, and differentiation into the various hematopoietic lineages. This highly organized factory requires cross talk between hematopoietic and stromal elements in distinct microanatomical sites (niches), promoting the expansion of normal hematopoietic elements and the deletion of defective and potentially harmful cells [1]. The neoplastic cells from patients with lymphoid malignancies take advantage of the BM microenvironment by parasitizing niches that normally are restricted to hematopoietic progenitors [2]. Interactions with the marrow microenvironment contribute to malignant B cell growth and drug resistance, leading to a gradual replacement of normal hematopoiesis. In lymphoid malignancies, the BM also is a common site for residual disease and relapses after conventional therapies [3]. Therefore, there is growing interest in understanding the biology of the BM microenvironment. Over the last two decades, there has been substantial progress in identifying key cellular and molecular players in cross talk between malignant lymphocytes and the marrow microenvironment. In this chapter, we will highlight established pathways and current therapeutic approaches to target the microenvironment in acute and chronic B cell malignancies.

Original languageEnglish (US)
Title of host publicationBone Marrow Lymphoid Infiltrates
Subtitle of host publicationDiagnosis and Clinical Impact
PublisherSpringer-Verlag London Ltd
Pages35-45
Number of pages11
ISBN (Electronic)9781447141747
ISBN (Print)1447141733, 9781447141730
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Burger, J. A., & Sipkins, D. A. (2013). The bone marrow microenvironment and its impact in acute and chronic B cell malignancies. In Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact (pp. 35-45). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-4174-7_3