TY - JOUR
T1 - The Cancer Family Syndrome Rare Cutaneous Phenotypic Linkage of Torre's Syndrome
AU - Lynch, Henry T.
AU - Lynch, Patrick M.
AU - Pester, Judith
AU - Fusaro, Ramon M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1981/4
Y1 - 1981/4
N2 - Sebaceous neoplasia have been observed in members of four families exhibiting the cancer family syndrome (CFS). This disorder is characterized by adenocarcinomas, particularly involving the (proximal) colon, endometrium, and ovary; an excess of multiple primary cancer; early age of cancer onset; and autosomal dominant pattern of inheritance. Multiple adenomatous polyps are lacking in this disorder. In four patients from three of these cancer-prone kindreds, cutaneous lesions were accompanied by multiple visceral adenocarcinomas, fulfilling the criteria for Torre's syndrome, a disease that heretofore has not shown notable familial clustering characteristic of the CFS. Therefore, the coexistence of rare sebaceous neoplasia and visceral cancer in CFS supports the notion that some cases of Torre's syndrome may in fact represent the more full phenotypic expression of the gene responsible for the CFS.
AB - Sebaceous neoplasia have been observed in members of four families exhibiting the cancer family syndrome (CFS). This disorder is characterized by adenocarcinomas, particularly involving the (proximal) colon, endometrium, and ovary; an excess of multiple primary cancer; early age of cancer onset; and autosomal dominant pattern of inheritance. Multiple adenomatous polyps are lacking in this disorder. In four patients from three of these cancer-prone kindreds, cutaneous lesions were accompanied by multiple visceral adenocarcinomas, fulfilling the criteria for Torre's syndrome, a disease that heretofore has not shown notable familial clustering characteristic of the CFS. Therefore, the coexistence of rare sebaceous neoplasia and visceral cancer in CFS supports the notion that some cases of Torre's syndrome may in fact represent the more full phenotypic expression of the gene responsible for the CFS.
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U2 - 10.1001/archinte.1981.00340050059016
DO - 10.1001/archinte.1981.00340050059016
M3 - Article
C2 - 7224741
AN - SCOPUS:0019515269
SN - 0003-9926
VL - 141
SP - 607
EP - 611
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 5
ER -