The cancer genome

Michael R. Stratton; Peter J. Campbell; P. Andrew Futreal

doi:10.1038/nature07943

The cancer genome

Michael R. Stratton, Peter J. Campbell, P. Andrew Futreal

Research output: Contribution to journal › Review article › peer-review

2600 Scopus citations

Abstract

All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

Original language	English (US)
Pages (from-to)	719-724
Number of pages	6
Journal	Nature
Volume	458
Issue number	7239
DOIs	https://doi.org/10.1038/nature07943
State	Published - Apr 9 2009
Externally published	Yes

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10.1038/nature07943

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title = "The cancer genome",

abstract = "All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.",

author = "Stratton, {Michael R.} and Campbell, {Peter J.} and Futreal, {P. Andrew}",

note = "Funding Information: Acknowledgements We would like to thank N. Rahman for comments on the manuscript, G. Tang and B. Barrell for contributions to the figures and the Kay Kendall Leukaemia Fund and the Wellcome Trust for support.",

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AU - Campbell, Peter J.

AU - Futreal, P. Andrew

N1 - Funding Information: Acknowledgements We would like to thank N. Rahman for comments on the manuscript, G. Tang and B. Barrell for contributions to the figures and the Kay Kendall Leukaemia Fund and the Wellcome Trust for support.

PY - 2009/4/9

Y1 - 2009/4/9

N2 - All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

AB - All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

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The cancer genome

Abstract

ASJC Scopus subject areas

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