The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

Ma Qing; Dan Jones; Timothy A. Springer

doi:10.1016/S1074-7613(00)80046-1

The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

Ma Qing, Dan Jones, Timothy A. Springer

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581 Scopus citations

Abstract

We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor- derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone mar, row but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.

Original language	English (US)
Pages (from-to)	463-471
Number of pages	9
Journal	Immunity
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/S1074-7613(00)80046-1
State	Published - Apr 1999
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/S1074-7613(00)80046-1

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title = "The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment",

abstract = "We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor- derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone mar, row but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.",

author = "Ma Qing and Dan Jones and Springer, {Timothy A.}",

note = "Funding Information: We thank Frederick Alt, Eric Fedyk, Wojciech Swat, and Richard Van Etten for reviewing this manuscript. We thank Mark Ryan for cell sorting. Q. M. and D. J. are supported by grants from the Irvington Institute, Cancer Research Institute, and the National Institutes of Health. This work was supported by National Institutes of Heath Grant HL-48675. ",

year = "1999",

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doi = "10.1016/S1074-7613(00)80046-1",

language = "English (US)",

volume = "10",

pages = "463--471",

journal = "Immunity",

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T1 - The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

AU - Qing, Ma

AU - Jones, Dan

AU - Springer, Timothy A.

N1 - Funding Information: We thank Frederick Alt, Eric Fedyk, Wojciech Swat, and Richard Van Etten for reviewing this manuscript. We thank Mark Ryan for cell sorting. Q. M. and D. J. are supported by grants from the Irvington Institute, Cancer Research Institute, and the National Institutes of Health. This work was supported by National Institutes of Heath Grant HL-48675.

PY - 1999/4

Y1 - 1999/4

N2 - We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor- derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone mar, row but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.

AB - We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor- derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone mar, row but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.

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The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

Abstract

ASJC Scopus subject areas

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