The controversial role of microglia in malignant gliomas

Jun Wei; Konrad Gabrusiewicz; Amy Heimberger

doi:10.1155/2013/285246

The controversial role of microglia in malignant gliomas

Jun Wei
, Konrad Gabrusiewicz
, Amy Heimberger

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

191 Scopus citations

Abstract

Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

Original language	English (US)
Article number	285246
Journal	Clinical and Developmental Immunology
Volume	2013
DOIs	https://doi.org/10.1155/2013/285246
State	Published - 2013

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1155/2013/285246

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title = "The controversial role of microglia in malignant gliomas",

abstract = "Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.",

author = "Jun Wei and Konrad Gabrusiewicz and Amy Heimberger",

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T1 - The controversial role of microglia in malignant gliomas

AU - Wei, Jun

AU - Gabrusiewicz, Konrad

AU - Heimberger, Amy

PY - 2013

Y1 - 2013

N2 - Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

AB - Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

UR - https://www.scopus.com/pages/publications/84881504052

UR - https://www.scopus.com/pages/publications/84881504052#tab=citedBy

U2 - 10.1155/2013/285246

DO - 10.1155/2013/285246

M3 - Review article

C2 - 23983766

AN - SCOPUS:84881504052

SN - 1740-2522

VL - 2013

JO - Clinical and Developmental Immunology

JF - Clinical and Developmental Immunology

M1 - 285246

ER -

The controversial role of microglia in malignant gliomas

Abstract

ASJC Scopus subject areas

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