The crystal structure and cytotoxicity of goniodiol-7-Monoacetate from goniothalamus amuyon

Yang Chang Wu, Chang Yih Duh, Fang Rong Chang, Gwo Yuan Chang, Shang Kwei Wang, Jer Jang Chang, Donald R. McPhail, Andrew T. McPhail, Kuo Hsiung Lee

    Research output: Contribution to journalArticle

    67 Scopus citations

    Abstract

    The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R, 8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone}, has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic anaylsis. Goniodiol-7-monoacetate showed potent (ED50 values <0.1 μg/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.

    Original languageEnglish (US)
    Pages (from-to)1077-1081
    Number of pages5
    JournalJournal of Natural Products
    Volume54
    Issue number4
    DOIs
    StatePublished - Jul 1 1991

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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  • Cite this

    Wu, Y. C., Duh, C. Y., Chang, F. R., Chang, G. Y., Wang, S. K., Chang, J. J., McPhail, D. R., McPhail, A. T., & Lee, K. H. (1991). The crystal structure and cytotoxicity of goniodiol-7-Monoacetate from goniothalamus amuyon. Journal of Natural Products, 54(4), 1077-1081. https://doi.org/10.1021/np50076a024