The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity

Alexander Rühle, Peter Huber, Rainer Saffrich, Ramon Lopez Perez, Nils H. Nicolay

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Chemotherapeutic agents are part of the standard treatment algorithms for many malignancies; however, their application and dosage are limited by their toxic effects to normal tissues. Chemotherapy-induced toxicities can be long-lasting and may be incompletely reversible; therefore, causative therapies for chemotherapy-dependent side effects are needed, especially considering the increasing survival rates of treated cancer patients. Mesenchymal stem cells (MSCs) have been shown to exhibit regenerative abilities for various forms of tissue damage. Preclinical data suggest that MSCs may also help to alleviate tissue lesions caused by chemotherapeutic agents, mainly by establishing a protective microenvironment for functional cells. Due to the systemic administration of most anticancer agents, the effects of these drugs on the MSCs themselves are of crucial importance to use stem cell-based approaches for the treatment of chemotherapy-induced tissue toxicities. Here, we present a concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs. Molecular mechanisms underlying the effects are outlined, and resulting challenges of MSC-based treatments for chemotherapy-induced tissue injuries are discussed.

Original languageEnglish (US)
Pages (from-to)2628-2639
Number of pages12
JournalInternational Journal of Cancer
Volume143
Issue number11
DOIs
StatePublished - Dec 1 2018

Fingerprint

Mesenchymal Stromal Cells
Drug Therapy
Stem Cells
Cellular Microenvironment
Poisons
Therapeutics
Antineoplastic Agents
Neoplasms
Survival Rate
Survival
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • chemotherapy
  • mesenchymal stem cells
  • side effects
  • tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity. / Rühle, Alexander; Huber, Peter; Saffrich, Rainer; Lopez Perez, Ramon; Nicolay, Nils H.

In: International Journal of Cancer, Vol. 143, No. 11, 01.12.2018, p. 2628-2639.

Research output: Contribution to journalReview article

Rühle, Alexander ; Huber, Peter ; Saffrich, Rainer ; Lopez Perez, Ramon ; Nicolay, Nils H. / The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity. In: International Journal of Cancer. 2018 ; Vol. 143, No. 11. pp. 2628-2639.
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