The DNA damage response pathways: At the crossroad of protein modifications

Michael S.Y. Huen, Junjie Chen

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Post-translational modifications play a crucial role in coordinating cellular response to DNA damage. Recent evidence suggests an interplay between multiple protein modifications, including phosphorylation, ubiquitylation, acetylation and sumoylation, that combine to propagate the DNA damage signal to elicit cell cycle arrest, DNA repair, apoptosis and senescence. Utility of specific post-translational modifiers allows temporal and spatial control over protein relocalization and interactions, and may represent a means for trans-regulatory activation of protein activities. The ability to recognize these specific modifiers also underscores the capacity for signal amplification, a crucial step for the maintenance of genomic stability and tumor prevention. Here we have summarized recent findings that highlight the complexity of post-translational modifications in coordinating the DNA damage response, with emphasis on the DNA damage signaling cascade.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalCell research
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

DNA Damage
Post Translational Protein Processing
Proteins
Sumoylation
Genomic Instability
Ubiquitination
Acetylation
Cell Cycle Checkpoints
DNA Repair
Maintenance
Phosphorylation
Apoptosis
Neoplasms

Keywords

  • Genomic instability and cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

The DNA damage response pathways : At the crossroad of protein modifications. / Huen, Michael S.Y.; Chen, Junjie.

In: Cell research, Vol. 18, No. 1, 01.01.2008, p. 8-16.

Research output: Contribution to journalReview article

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