The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat

Susan Abend; Janice Cormier; Micheal C. Appel; Wasana Lueprasitsakul; Sharon Alex; John P. Mordes; K. H. Usadel; Eugene S. Handler; Aldo A. Rossini; Lewis E. Braverman

doi:10.1016/0162-3109(90)90065-M

The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat

Susan Abend
, Janice Cormier
, Micheal C. Appel
, Wasana Lueprasitsakul
, Sharon Alex
, John P. Mordes
, K. H. Usadel
, Eugene S. Handler
, Aldo A. Rossini
, Lewis E. Braverman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T₄ concentrations.

Original language	English (US)
Pages (from-to)	163-168
Number of pages	6
Journal	Immunopharmacology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(90)90065-M
State	Published - 1990
Externally published	Yes

Keywords

BB rat
Ciamexone
IDDM
Lymphocytic thyroiditis

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0162-3109(90)90065-M

Cite this

@article{c98a5c66a0414ff3a5dcaeff7c3b3a2b,

title = "The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat",

abstract = "Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations.",

keywords = "BB rat, Ciamexone, IDDM, Lymphocytic thyroiditis",

author = "Susan Abend and Janice Cormier and Appel, \{Micheal C.\} and Wasana Lueprasitsakul and Sharon Alex and Mordes, \{John P.\} and Usadel, \{K. H.\} and Handler, \{Eugene S.\} and Rossini, \{Aldo A.\} and Braverman, \{Lewis E.\}",

note = "Funding Information: We thank Olita Treimanis and Marissa Lopez for technical assistance. This work was supported in part by grants from Boehringer Mannheim Pharmaceuticals Division, Rockville, MD, and by grants DK41235, DK36024, DK07302 and DK18919 from the National Institutes of Health.",

year = "1990",

doi = "10.1016/0162-3109(90)90065-M",

language = "English (US)",

volume = "19",

pages = "163--168",

journal = "Immunopharmacology",

issn = "0162-3109",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat

AU - Abend, Susan

AU - Cormier, Janice

AU - Appel, Micheal C.

AU - Lueprasitsakul, Wasana

AU - Alex, Sharon

AU - Mordes, John P.

AU - Usadel, K. H.

AU - Handler, Eugene S.

AU - Rossini, Aldo A.

AU - Braverman, Lewis E.

N1 - Funding Information: We thank Olita Treimanis and Marissa Lopez for technical assistance. This work was supported in part by grants from Boehringer Mannheim Pharmaceuticals Division, Rockville, MD, and by grants DK41235, DK36024, DK07302 and DK18919 from the National Institutes of Health.

PY - 1990

Y1 - 1990

N2 - Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations.

AB - Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations.

KW - BB rat

KW - Ciamexone

KW - IDDM

KW - Lymphocytic thyroiditis

UR - https://www.scopus.com/pages/publications/0025331613

UR - https://www.scopus.com/pages/publications/0025331613#tab=citedBy

U2 - 10.1016/0162-3109(90)90065-M

DO - 10.1016/0162-3109(90)90065-M

M3 - Article

C2 - 2394579

AN - SCOPUS:0025331613

SN - 0162-3109

VL - 19

SP - 163

EP - 168

JO - Immunopharmacology

JF - Immunopharmacology

IS - 3

ER -

The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this