The effect of cyclic AMP and prostaglandins on the fibrinolytic activity of mouse neuroblastoma cells

W. E. Laug; P. A. Jones; C. A. Nye; W. F. Benedict

doi:10.1016/0006-291X(76)90017-6

The effect of cyclic AMP and prostaglandins on the fibrinolytic activity of mouse neuroblastoma cells

W. E. Laug, P. A. Jones, C. A. Nye, W. F. Benedict

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The C1300 mouse neuroblastoma cell line was found to produce plasminogen activator which is secreted into the growth medium. The intra- and extracellular activities of this enzyme were markedly increased (up to 14 fold) by treatment with cyclic AMP agents. Prostaglandins E₁ and E₂ and butyric acid were the most efficient inducers followed by propionic acid and dibutyryl cyclic AMP. Theophylline was found to be ineffective. The highest enzyme activities were found in cells exposed simultaneously to prostaglandin E₁ and dibutyryl cyclic AMP.

Original language	English (US)
Pages (from-to)	114-119
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(76)90017-6
State	Published - Jan 12 1976

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "The C1300 mouse neuroblastoma cell line was found to produce plasminogen activator which is secreted into the growth medium. The intra- and extracellular activities of this enzyme were markedly increased (up to 14 fold) by treatment with cyclic AMP agents. Prostaglandins E1 and E2 and butyric acid were the most efficient inducers followed by propionic acid and dibutyryl cyclic AMP. Theophylline was found to be ineffective. The highest enzyme activities were found in cells exposed simultaneously to prostaglandin E1 and dibutyryl cyclic AMP.",

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AU - Nye, C. A.

AU - Benedict, W. F.

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N2 - The C1300 mouse neuroblastoma cell line was found to produce plasminogen activator which is secreted into the growth medium. The intra- and extracellular activities of this enzyme were markedly increased (up to 14 fold) by treatment with cyclic AMP agents. Prostaglandins E1 and E2 and butyric acid were the most efficient inducers followed by propionic acid and dibutyryl cyclic AMP. Theophylline was found to be ineffective. The highest enzyme activities were found in cells exposed simultaneously to prostaglandin E1 and dibutyryl cyclic AMP.

AB - The C1300 mouse neuroblastoma cell line was found to produce plasminogen activator which is secreted into the growth medium. The intra- and extracellular activities of this enzyme were markedly increased (up to 14 fold) by treatment with cyclic AMP agents. Prostaglandins E1 and E2 and butyric acid were the most efficient inducers followed by propionic acid and dibutyryl cyclic AMP. Theophylline was found to be ineffective. The highest enzyme activities were found in cells exposed simultaneously to prostaglandin E1 and dibutyryl cyclic AMP.

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The effect of cyclic AMP and prostaglandins on the fibrinolytic activity of mouse neuroblastoma cells

Abstract

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