The effect of inhibitors of alcohol metabolism upon the changes in the hepatic microsomal metabolism of foreign compounds produced by the acute administration of some alcohols to the rat

Garth Powis, Lindsay Grant

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Pyrazole administered to rats 24 hr previously produced an increase in hepatic microsomal aniline hydroxylation and a decrease in aminopyrine demethylation. This was a direct effect and not a consequence of the inhibition of the metabolism of endogenously produced ethanol. Acetaldehyde oxime had no effect upon aniline hydroxylation but produced a small decrease in aminopyrine demethylation. Both inhibitors of alcohol dehydrogenase potentiated the increase in aniline hydroxylation produced by submaximal doses of methanol and ethanol, suggesting that this was a direct effect produced by the alcohols themselves. The decrease in aminopyrine demethylation produced by methanol and ethanol was partly reversed by inhibitors of alcohol dehydrogenase, suggesting that this effect resulted from the metabolism of the alcohols. Formaldehyde and acetaldehyde administered to rats had no effect upon aniline hydroxylation but both produced a decrease in aminopyrine demethylation and in the type I spectral change. The inhibitory effect of submaximal doses of the aldehydes upon aminopyrine demethylation was potentiated by disulphiram, an inhibitor of aldehyde dehydrogenase. Inhibitors of alcohol dehydrogenase had no effect upon the increase in aniline hydroxylation produced by propan-2-ol, nor was their effect upon aminopyrine demethylation modified in any consistent way by propan-2-ol.

Original languageEnglish (US)
Pages (from-to)2197-2201
Number of pages5
JournalBiochemical Pharmacology
Volume25
Issue number19
DOIs
StatePublished - Oct 1 1976

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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