The effect of regulatory T cells level in peripheral blood on the prognosis in HCC patients after TACE

Hu Zi Li, Zhi Guo, Hai Tao Wang, Tong Guo Si, Chang Fu Liu, Hai Peng Yu

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    Abstract

    Objective: To discuss the correlation between regulatory T cells (Treg) level in peripheral blood and the prognosis in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods: A total of 122 patients with HCC who received TACE at authors' hospital were enrolled in this study. The CD3+ T, CD4+ T, CD8+ T, NK and Treg levels in peripheral blood were assessed by flow cytometry method. The relationship between the Treg level in peripheral blood and the survival time was evaluated by Cox regression and Kaplan-Meier analysis. Results: In HCC patients after TACE, the ratio of Treg cells to CD4+ T was significantly increased (6.109 and 6.834.P = 0.000). In lower ratio group (ratio of Treg cells to CD4+ T < 6.7), the median survival time of patients was 19.3 months, while in higher ratio group (ratio of Treg cells to CD4+ T ≥ 6.7), the median survival time of patients was 12.0 months. The difference between the two groups was statistically significant by using single factor analysis (χ2 = 8.771, P = 0.003) or multivariate analysis (P = 0.020). Conclusion: The Treg level in peripheral blood is an independent predictive factor for judging the prognosis of HCC patients after TACE.

    Original languageEnglish (US)
    Pages (from-to)998-1001
    Number of pages4
    JournalJournal of Interventional Radiology (China)
    Volume21
    Issue number12
    DOIs
    StatePublished - Nov 2012

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    Keywords

    • Immunologic function
    • Prognosis
    • Regulatory T cell
    • Transcatheter arterial chemoembolization

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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