The effects of hempseed meal intake and linoleic acid on drosophila models of neurodegenerative diseases and hypercholesterolemia

Min Jung Lee, Seung Hwan Park, Ju Hua Han, Yoon Ki Hong, Soojin Hwang, Soojin Lee, Darae Kim, Seung Yeop Han, Eun Soo Kim, Kyoung Sang Cho

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Hempseed is rich in polyunsaturated fatty acids (PUFAs), which have potential as therapeutic compounds for the treatment of neurodegenerative and cardiovascular disease. However, the effect of hempseed meal (HSM) intake on the animal models of these diseases has yet to be elucidated. In this study, we assessed the effects of the intake of HSM and PUFAs on oxidative stress, cytotoxicity and neurological phenotypes, and cholesterol uptake, using Drosophila models. HSM intake was shown to reduce H2O2 toxicity markedly, indicating that HSM exerts a profound antioxidant effect. Meanwhile, intake of HSM, as well as linoleic or linolenic acids (major PUFA components of HSM) was shown to ameliorate Aβ42-induced eye degeneration, thus suggesting that these compounds exert a protective effect against Aβ42 cytotoxicity. On the contrary, locomotion and longevity in the Parkinson's disease model and eye degeneration in the Huntington's disease model were unaffected by HSM feeding. Additionally, intake of HSM or linoleic acid was shown to reduce cholesterol uptake significantly. Moreover, linoleic acid intake has been shown to delay pupariation, and cholesterol feeding rescued the linoleic acid-induced larval growth delay, thereby indicating that linoleic acid acts antagonistically with cholesterol during larval growth. In conclusion, our results indicate that HSM and linoleic acid exert inhibitory effects on both Aβ42 cytotoxicity and cholesterol uptake, and are potential candidates for the treatment of Alzheimer's disease and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalMolecules and cells
Volume31
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cholesterol
  • Drosophila
  • Hempseed meal
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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