The effects of intermittent progesterone upon tamoxifen inhibition of tumor growth in the 7,12-dimethylbenzanthracene rat mammary tumor model

David FC Gibson, Delinda A. Johnson, Susan M. Langan-Fahey, Mary K. Lababidi, William H. Wolberg, Virgil Craig Jordan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The development of endometrial cancer is a potential risk during long-term tamoxifen therapy for breast cancer. In order to protect the uterus, progestin treatment has been proposed for these patients. However, within the 7,12-dimethylbenzanthracene-induced rat mammary model, progesterone is known to reverse the antitumor effects of tamoxifen. This study shows that progesterone administered intermittently still reverses the antitumor effects of tamoxifen in this model. This effect of progesterone is not due to a decrease in the tissue levels of tamoxifen, and may be direct, via the progesterone receptor.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalBreast Cancer Research and Treatment
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1993

Keywords

  • 7,12-dimethylbenzanthracene
  • progesterone
  • rat mammary tumor
  • tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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