The emerging molecular machinery and therapeutic targets of metastasis

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Metastasis is a 100-year-old research topic. Technological advances during the past few decades have led to significant progress in our understanding of metastatic disease. However, metastasis remains the leading cause of cancer-related mortalities. The lack of appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are major obstacles in metastasis prevention and treatment. Numerous processes, factors, and signaling pathways are involved in regulating metastasis. Here we discuss recent progress in metastasis research, including epithelial-mesenchymal plasticity, cancer stem cells, emerging molecular determinants and therapeutic targets, and the link between metastasis and therapy resistance.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalTrends in Pharmacological Sciences
Volume36
Issue number6
DOIs
StatePublished - Jan 1 2015

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Machinery
Neoplasm Metastasis
Stem cells
Plasticity
Therapeutics
Pharmaceutical Preparations
Neoplastic Stem Cells
Research
Clinical Trials
Mortality
Neoplasms

Keywords

  • Cancer stem cell
  • Circulating tumor cell
  • Epithelial-mesenchymal plasticity
  • Metastasis
  • Therapy resistance

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

The emerging molecular machinery and therapeutic targets of metastasis. / Sun, Yutong; Ma, Li.

In: Trends in Pharmacological Sciences, Vol. 36, No. 6, 01.01.2015, p. 349-359.

Research output: Contribution to journalReview article

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