TY - JOUR
T1 - The emerging molecular machinery and therapeutic targets of metastasis
AU - Sun, Yutong
AU - Ma, Li
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Metastasis is a 100-year-old research topic. Technological advances during the past few decades have led to significant progress in our understanding of metastatic disease. However, metastasis remains the leading cause of cancer-related mortalities. The lack of appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are major obstacles in metastasis prevention and treatment. Numerous processes, factors, and signaling pathways are involved in regulating metastasis. Here we discuss recent progress in metastasis research, including epithelial-mesenchymal plasticity, cancer stem cells, emerging molecular determinants and therapeutic targets, and the link between metastasis and therapy resistance.
AB - Metastasis is a 100-year-old research topic. Technological advances during the past few decades have led to significant progress in our understanding of metastatic disease. However, metastasis remains the leading cause of cancer-related mortalities. The lack of appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are major obstacles in metastasis prevention and treatment. Numerous processes, factors, and signaling pathways are involved in regulating metastasis. Here we discuss recent progress in metastasis research, including epithelial-mesenchymal plasticity, cancer stem cells, emerging molecular determinants and therapeutic targets, and the link between metastasis and therapy resistance.
KW - Cancer stem cell
KW - Circulating tumor cell
KW - Epithelial-mesenchymal plasticity
KW - Metastasis
KW - Therapy resistance
UR - http://www.scopus.com/inward/record.url?scp=84934890113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934890113&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2015.04.001
DO - 10.1016/j.tips.2015.04.001
M3 - Review article
C2 - 25939811
AN - SCOPUS:84934890113
SN - 0165-6147
VL - 36
SP - 349
EP - 359
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -