The emerging roles of exosomes in the modulation of immune responses in cancer

Paul Kurywchak; Jena Tavormina; Raghu Kalluri

doi:10.1186/s13073-018-0535-4

The emerging roles of exosomes in the modulation of immune responses in cancer

Paul Kurywchak, Jena Tavormina, Raghu Kalluri

Cancer Biology

Research output: Contribution to journal › Comment/debate › peer-review

80 Scopus citations

Abstract

Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.

Original language	English (US)
Article number	23
Journal	Genome medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13073-018-0535-4
State	Published - Mar 26 2018

Keywords

Biomarker
Cancer
DNA
Drug delivery
Exosomes
Innate immunity
STING

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/s13073-018-0535-4

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AB - Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.

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KW - Innate immunity

KW - STING

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The emerging roles of exosomes in the modulation of immune responses in cancer

Abstract

Keywords

ASJC Scopus subject areas

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