Abstract
This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are identified in the squamous esophagus; dilated intercellular spaces; the metastasizing potential of early carcinoma-dependent, molecular or immunohistochemical tests that improve diagnosis; the role of immunohistochemistry IHC in grading of neoplasia in Barrett's esophagus and defining the risk of progression to adenocarcinoma; the roles of CDX1 and CDX2 in squamous and cardiac mucosa; and the role of desmosomal cadherins and lectins in squamous and cardiac mucosa.
Original language | English (US) |
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Pages (from-to) | 144-165 |
Number of pages | 22 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1300 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2013 |
Keywords
- Dilated intercellular spaces
- Eosinophilic esophagitis
- Lamina propria
- Markers
- Multilayered epithelium
- Muscularis mucosae
- Transcription factors
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- History and Philosophy of Science