The esophageal mucosa and submucosa: Immunohistology in GERD and Barrett's esophagus

Henry D. Appelman, Catherine Streutker, Michael Vieth, Helmut Neumann, Markus F. Neurath, Melissa P. Upton, Xavier Sagaert, Helen H. Wang, Hala El-Zimaity, Susan C. Abraham, Andrew M. Bellizzi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are identified in the squamous esophagus; dilated intercellular spaces; the metastasizing potential of early carcinoma-dependent, molecular or immunohistochemical tests that improve diagnosis; the role of immunohistochemistry IHC in grading of neoplasia in Barrett's esophagus and defining the risk of progression to adenocarcinoma; the roles of CDX1 and CDX2 in squamous and cardiac mucosa; and the role of desmosomal cadherins and lectins in squamous and cardiac mucosa.

Original languageEnglish (US)
Pages (from-to)144-165
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
StatePublished - Oct 2013

Keywords

  • Dilated intercellular spaces
  • Eosinophilic esophagitis
  • Lamina propria
  • Markers
  • Multilayered epithelium
  • Muscularis mucosae
  • Transcription factors

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science

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