Abstract
Anti-Ri is a human autoantibody that recognizes a neuronal nuclear antigen (Ri) of unknown function. To ascertain the possible role of the Ri antigen in neuronal development, we analysed the pattern of the anti-Ri immunoreactivity in the developing rat nervous system. Neurons of the retina, except the photoreceptors, and central but not peripheral nervous system were anti-Ri-positive. The intensity of the immunoreactivity followed the sequence of neuronal maturation. Germinal cells of the periventricular layer and migrating neuroblasts in the intermediate zone were Ri-negative. These data suggest Ri antigen may play a role in the postmigratory maturation of neurons of the CNS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-144 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 162 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 12 1993 |
| Externally published | Yes |
Keywords
- Autoantibody
- Immunohistochemistry
- Neuronal antigen
- Neuronal development
- Paraneoplastic disease
- Retina
ASJC Scopus subject areas
- General Neuroscience
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