Objective: To investigate the effect of Twist, β-catenin and E-cadherin on the recurrence and metastasis of hepatocellular carcinoma (HCC) and its correlation with clinical prognosis. Methods: Immunohistochemical staining (SP) was conducted to detect the expression of Twist, β-catenin and E-cadherin in 97 hepatocellular carcinoma patients (49 with recurrence and metastasis and 48 without recurrence and metastasis). Results: The recurrence and metastasis of HCC were correlated with clinical stage (F=0.000), but were not correlated with sex or age (F=0.424, P=0.738). The abnormal expression of Twist and β-catenin in the recurrence and metastasis group was higher than that in the group without recurrence or metastasis (F=0.000, P=0.000). The positive ratio of E-cadherin in the recurrence and metastasis group was lower than that in the group without recurrence or metastasis (P=0.027). The mean survival was 28.880±3.285 months in patients with positive expression of Twist and 31.477±3.359 months in patients with positive expression of β-catenin. The median survival time of them was 26 and 28 months, respctively. The mean survival was 44.603±3.521 months in patients without Twist expression and 42.009±3.720 months in patients without β-catenin expression. The median survival time of them was 49 and 45 months, respectively. The survival of patients with positive expression of Twist and β-catenin was shorter than that in patients without expression of Twist and β-catenin (P=0.002, P=0.029). The mean survival time and median survival time of patients with Twist and β-catenin expression were 44.514±3.447 months and 49 months, respectively, significantly higher than those in patients without Twist and β-catenin expression (P=0.002), which were 29.110±3.581 months and 25 months, respectively. Conclusion: The overexpression of Twist and β-catenin as well as decreased expression of E-cadherin may play critical roles in the recurrence and metastasis of HCC and indicate poor prognosis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Journal of Clinical Oncology|
|State||Published - Mar 1 2010|
- Recurrence and metastasis
ASJC Scopus subject areas
- Cancer Research