TY - JOUR
T1 - The functions and regulation of the PTEN tumour suppressor
AU - Song, Min Sup
AU - Salmena, Leonardo
AU - Pandolfi, Pier Paolo
N1 - Funding Information:
The authors are grateful to all members of the Pandolfi laboratory for insightful comments and discussion. The authors also thank H. M. Kim for providing the modified PTEN structures. L.S. was supported by fellowships from the Canadian Institutes of Health Research and the Human Frontier Science Program. This work was supported by US National Institutes of Health (NIH) grant R01 CA-82328-09 awarded to P.P.P.
PY - 2012/5
Y1 - 2012/5
N2 - The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation by non-coding RNAs, post-translational modifications and proteing-protein interactions, are all altered in cancer. The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus. Our increasing knowledge of PTEN and pathologies in which its function is altered will undoubtedly inform the rational design of novel therapies.
AB - The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation by non-coding RNAs, post-translational modifications and proteing-protein interactions, are all altered in cancer. The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus. Our increasing knowledge of PTEN and pathologies in which its function is altered will undoubtedly inform the rational design of novel therapies.
UR - https://www.scopus.com/pages/publications/84860217431
UR - https://www.scopus.com/pages/publications/84860217431#tab=citedBy
U2 - 10.1038/nrm3330
DO - 10.1038/nrm3330
M3 - Review article
C2 - 22473468
AN - SCOPUS:84860217431
SN - 1471-0072
VL - 13
SP - 283
EP - 296
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 5
ER -